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IL1A — REN

Text-mined interactions from Literome

Bataillard et al., Am J Physiol 1992 : The purpose of this study was to determine whether human recombinant IL-1 ( hrIL-1 ) affects aldosterone output as well as renin and adrenocorticotropic hormone ( ACTH ) release, two key factors in the regulation of mineralocorticoid secretion
Antonipillai et al., Endocrinology 1990 : We have studied the direct effects of recombinant and purified TNF and IL-1 on renin secretion using both static incubations and perifusions of rat renal cortical slices ... Ultrapure human IL-1 ( hIL-1 ) at concentrations as low as 5 U/ml ( 3 X 10 ( -12 ) M ) significantly stimulated renin secretion ( control, 98 +/- 4 % ; hIL-1, 153 +/- 13 % ; P less than 0.01 ) ... The stimulatory effects of TNF and IL-1 on renin were reversible ... These results suggest that IL-1 and TNF are renin secretagogues and can also block the inhibitory actions of AII on renin ... Since the effect of TNF and IL-1 on renin can be blocked by a ( CO ) inhibitor, the studies indicate a role of prostaglandins in their action
Hermus et al., J Steroid Biochem Mol Biol 1990 : IL1 and TNF inhibit aldosterone production by rat adrenocortical cells in vitro and stimulate renin release by rat renal cortical cells