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IL1A — P2RX7

Text-mined interactions from Literome

Solle et al., J Biol Chem 2001 (Inflammation) : Absence of the P2X(7)R thus leads to an inability of peritoneal macrophages to release IL-1 in response to ATP
Brough et al., Mol Cell Neurosci 2002 (Encephalitis...) : Thus, IL-1beta is not required for P2X7 receptor stimulated microglial death
Verhoef et al., J Immunol 2005 : Inhibitory effects of chloride on the activation of caspase-1, IL-1beta secretion, and cytolysis by the P2X7 receptor
Pelegrin et al., J Immunol 2008 : We used peritoneal macrophage from P2X(7)R ( -/- ) mice and found that release of IL-1alpha , IL-18, as well as IL-1beta, by ATP resulted exclusively from activation of P2X(7)R , release of all these IL-1 cytokines involved pannexin-1 (panx1), and that there was both a panx1 dependent and -independent component to IL-1beta release
Hoque et al., Am J Physiol Gastrointest Liver Physiol 2012 (Drug-Induced Liver Injury...) : P2X7 was required for ATP stimulated IL-1ß release
Shi et al., Am J Respir Cell Mol Biol 2012 : Rhinovirus induced IL-1ß release from bronchial epithelial cells is independent of functional P2X7
Lee et al., PloS one 2012 (Acute Disease...) : We also showed that ATP-P2X(7)R signaling regulates inflammasome activation as inhibition or deficiency of P2X(7)R as well as caspase-1 significantly reduced IL-1ß secretion
Jalilian et al., Vet Immunol Immunopathol 2012 : P2X7 , a damage associated molecular pattern receptor and adenosine 5'-triphosphate ( ATP ) -gated cation channel, plays an important role in the activation of the NALP3 inflammasome and subsequent release of interleukin (IL)-1ß from human monocytes ; however its role in monocytes from other species including the dog remains poorly defined ... These results demonstrate that P2X7 activation induces the uptake of organic cations into and the release of IL-1ß from canine monocytes
Liao et al., J Leukoc Biol 2013 : Moreover, statin induced caspase-1 activation and IL-1ß production in LPS primed THP-1 cells are dependent on GGPP deficiency and P2X7 activation
Sakaki et al., Biochem Biophys Res Commun 2013 : The P2X7 dependent IL-1ß and IL-18 release was significantly lower in P2X4-KD cells