Gene interactions and pathways from curated databases and text-mining

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IL1A — NLRP1

Text-mined interactions from Literome

Mawhinney et al., BMC neuroscience 2011 (Disease Models, Animal...) : Our previous work has shown that among the members of this family, NLRP1/NALP1 , present in neurons, plays a crucial role in inflammasome formation and the production of the inflammatory cytokines interleukin (IL) -1ß and IL-18 after various types of central nervous system injury ... Our previous work has shown that among the members of this family, NLRP1/NALP1 , present in neurons, plays a crucial role in inflammasome formation and the production of the inflammatory cytokines interleukin (IL) -1ß and IL-18 after various types of central nervous system injury
Levinsohn et al., PLoS Pathog 2012 : Here we show that LT cleaves rat Nlrp1 and this cleavage is required for toxin induced inflammasome activation, IL-1 ß release, and macrophage pyroptosis
Luo et al., Clin Chem Lab Med 2013 (Cardiomyopathy, Dilated...) : In peripheral blood mononuclear cells ( PBMCs ), NLRP3 can activate interleukin-1ß (IL-1ß) , important in the chronic inflammatory process of idiopathic dilated cardiomyopathy ( IDCM )