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IL1A — MRXS5
Text-mined interactions from Literome
Irahara et al., Biol Reprod 1999
:
The dexamethasone effect was not limited to the
IL-1 mediated induction of
PGS-2 transcripts, comparable suppression being noted for the IL-1 mediated up-regulation of ovarian transcripts corresponding to IL-1beta, the IL-1 receptor antagonist, and the type I IL-1 receptor
Rauk et al., Am J Reprod Immunol 2000
:
With intrauterine infection,
IL-1 may
induce labor through the autocrine production of uterotonic
PGs
Matzkin et al., Mol Cell Endocrinol 2012
(MAP Kinase Signaling System) :
Our studies suggest that PRL
induces COX2/PGs in hamster Leydig cells through
IL-1ß and activation of P38-MAPK and JAK2
Dingle et al., J Lipid Mediat 1993
(Osteoarthritis) :
( 2 ) The synthesis of
IL1 can be
controlled by
prostaglandins (PGs) , which may explain why the inhibitory action can be at least partially overcome by the action of the PG analogue Misoprostol in the dose range 10-100 ng/ml
Watanobe et al., Cytokine 1995
:
Many studies have reported that
prostaglandins (PGs) , especially PGE2, in the brain may
mediate the
IL-1 stimulation of corticotropin releasing hormone release, which then leads to adrenocorticotropin ( ACTH ) secretion
Kol et al., Endocrinology 1997
:
These observations support the proposition that PLA2 may be a key component in the
IL-1 stimulated biosynthesis of ovarian
PGs