Jahan et al., Am J Physiol Gastrointest Liver Physiol 2005
(MAP Kinase Signaling System) :
Furthermore, IL-1beta inhibited HNF4alpha gene transcription, protein expression, and binding to the CYP8B1 gene
Li et al., Hepatology 2006
:
In conclusion, IL-1 beta and CDCA inhibit HNF4 alpha but induce c-Jun, which in turn blocks HNF 4 alpha recruitment of PGC-1 alpha to the CYP7A1 chromatin and results in inhibition of CYP7A1 gene transcription