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GPI — IL1A

Text-mined interactions from Literome

Beasley et al., Am J Physiol 1999 : A selective COX-2 inhibitor, NS-398, reversed IL-1 induced PGI2 and cAMP production, supporting a role of COX-2 in mediating increased PG synthesis
Toratani et al., J Cardiovasc Pharmacol 1999 : IL-1alpha did not increase PGI2 production for 15 min, but induced an increase of about three-fold relative to that in controls at 60 and 180 min. IL- 1alpha had no effect on intracellular Ca2+ levels throughout the experimental period ... These results suggest the existence of regulatory mechanisms of IL-1alpha induced PGI2 production, which involve PGHS and PLA2 gene transcription
Kahlke et al., Cytokine 2000 (Hemorrhage...) : In contrast, IL-1beta and IL-6 production by Mbeta from young males was suppressed and IL-10 production enhanced following trauma-haemorrhage, whereas Mstraight phi from aged males produced elevated levels of IL-1beta and IL-6 and suppressed levels of IL-10 following trauma-haemorrhage
Li et al., Acta Pharmacol Sin 2000 : Pre-transfection with antisense IRAK-2 ODN could remarkably decrease the levels of PGI2 synthesis induced by IL-1 in a time- and concentration dependent manner, whereas it could not attenuate the one stimulated by TNF
Houliston et al., Am J Physiol Cell Physiol 2001 (MAP Kinase Signaling System) : These results show that IL-1 alpha causes an acute upregulation of PGI ( 2 ) generation in HUVEC, establish a role for the MEK/ERK/cPLA(2)alpha pathway in this early release, and provide evidence for an agonist-specific cross talk between p38 ( mapk ) and p42/44(mapk) that may reflect receptor-specific differences in the signaling elements proximal to MAPK activation
McCarron et al., Cell Immunol 1992 : The ability of IL-1 to stimulate EC-derived PGI2 synthesis was dose dependent with maximal stimulation observed at 50 U/ml IL-1 ... The IL-1 induced production of PGI2 by EC as well as PGI2 production in cultures containing EC and either LNC or M phi was inhibited by treatment with anti-IL-1 antibody
Prajgrod et al., Agents Actions 1992 : While Dex was without effect, IL-1 and LPS stimulated PGI2 in a concentration- and time dependent manner
Briones et al., Mech Ageing Dev 2005 : IL-1ss also increased PGI ( 2 ) levels and COX-2 expression in the three layers of the vascular wall
Dianzani et al., Journal of inflammation (London, England) 2006 : Neither compounds modified PGE2 or PGI2 production induced by IL-1alpha
Danon et al., Agents Actions 1991 : In vitro IL-1 alpha stimulated aortic PGI2 synthesis
Szabo et al., J Clin Immunol 1991 (Burns...) : Interleukin-6 induction by FcRI stimulation is not mediated solely by FcRI induced M phi tumor necrosis factor alpha, IL-1 alpha , or IL-1 beta production and is independent of M phi prostaglandin E2 levels
Lerner et al., Biochem Biophys Res Commun 1991 (Bone Resorption) : Bradykinin ( BK ; 10 nmol/l ) synergistically potentiated the effect of IL-1 alpha ( 10 pg/ml ) and IL-1 beta ( 5 pg/ml ) both on 45Ca release and on biosynthesis of PGE2 and PGI2
Galán et al., J Hypertens 2011 : IL-1ß up-regulated COX-2 and mPGES-1 ( protein and mRNA ) and increased PGI2 and PGE2 release, without altering PGIS protein expression ... Interestingly, Ang II further enhanced IL-1ß induced COX-2 expression and PGI2 release and concomitantly reduced IL-1ß induced mPGES-1 expression
Endo et al., Biochem Biophys Res Commun 1988 : Both IL-1 and TNF increased PGI2 production by EC in both a time- and dose dependent manner, and a combination of the two cytokines additively enhanced PGI2 production
Leiter et al., J Exp Med 1987 : The potential pathological consequences of the chemoattractive action of insulin on M phi , and the inhibitory effect of IL-1 on insulin secretion, are discussed
Kunkel et al., Int J Dermatol 1986 : We recently have presented data demonstrating that lipoxygenase derived leukotriene B4 and C4 can induce the release of IL-1 by macrophages, while PGE2 and PGI2 can suppress the production of IL-1
Spisni et al., Exp Cell Res 1995 : Under the first condition, basal PGI2 production was unaffected while, in the presence of IL-1 alpha , a marked stimulation of PGI2 synthesis was observed
Levesque et al., Br J Pharmacol 1993 : The cell model retains some of the cardinal properties of B1 receptor mediated vascular responses : endothelium independent PGI2 release and up-regulation by the cytokine IL-1
Funaki et al., J Surg Res 1993 (Carcinoma, Hepatocellular...) : In our basic studies, HHM phi increased dose dependently the release of superoxide ( O2- ) and interleukin-1 (IL-1) when stimulated by opsonized zymosan, up to 1000 micrograms/dish
Schofield et al., J Immunol 1996 : The direct activation of endothelial cells by GPI does not require the participation of TNF or IL-1
Todd et al., J Matern Fetal Med 1996 : IL-1 , but not IL-6 or IL-8, caused a dose- and time dependent increase in the production of both PGI2 and PGE2
Henke et al., J Surg Res 1997 (Staphylococcal Infections) : Indomethacin completely prevented M phi Ia suppression, while anti-IL-1 alpha only partially ( 94 % ) prevented M phi Ia suppression with a corresponding decrease in PGE2 production in infected grafts
Sasaki et al., Blood 1997 (Hematologic Neoplasms...) : Phorbol 12-myristate 13-acetate ( PMA ), interleukin-1 (IL-1) , IL-3, IL-6, granulocyte-macrophage colony stimulating factor ( GM-CSF ), thrombopoietin (TPO), and tumor necrosis factor-alpha (TNF-alpha) enhanced PGI2-R mRNA expression
Wen et al., Cell Biol Int 1997 : LPS, IL-1 beta and TNF alpha effectively enhanced BK-stimulated production of PGI2 by HPASMC, while IFN gamma had only a weak effect on BK-stimulated PGI2 production ... Bradykinin induced enhancement of PGI2 production by LPS, IL-1 beta and TNF alpha might be involved in the regulation of pulmonary vascular tension and prevent a paradoxical thrombogenic effect in endotoxin- or cytokine mediated inflammation and acute lung injury