Gopal et al., Cell cycle (Georgetown, Tex.) 2006
(Inflammation) :
We recently reported that pro-inflammatory signals such as tumor necrosis factor alpha (TNFalpha) induce HDAC1 ubiquitination and proteasomal degradation through the IkappaB kinase IKKbeta Chavey et al., Mol Pharmacol 2008
(Breast Neoplasms) :
HDAC inhibitors triggered IKK phosphorylation and up-regulated p65 nuclear translocation, although they decreased the protein levels of IkappaBalpha, which accounts for NF-kappaB activation