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IGFBP1 — MAPK15

Text-mined interactions from Literome

Seto-Young et al., J Clin Endocrinol Metab 2003 (MAP Kinase Signaling System) : The role of mitogen activated protein kinase in insulin and insulin-like growth factor I (IGF-I) signaling cascades for progesterone and IGF binding protein-1 production in human granulosa cells ... We now examined whether activation of MAPK is necessary to mediate insulin induced or IGF-I induced stimulation of progesterone or inhibition of IGFBP-1 production in human granulosa cells ... We conclude that, under conditions of our experiments, insulin induced stimulation of progesterone or inhibition of IGFBP-1 production in human granulosa cells does not require MAPK activation, whereas similar effects of IGF-I are largely MAPK dependent
Velarde et al., Endocrinology 2009 (Endometriosis) : The MAPK kinase-1/2 inhibitor, U0126, fully restored cAMP down-regulation of CCND1, but not cAMP up-regulation of IGFBP1 , in hESF of women with vs. without endometriosis