◀ Back to IGF1
CYP19A1 — IGF1
Text-mined interactions from Literome
Silva et al., J Endocrinol 2002
:
Insulin and
IGF-I are
necessary for FSH induced cytochrome P450
aromatase but not cytochrome P450 side-chain cleavage gene expression in oestrogenic bovine granulosa cells in vitro
Kagawa et al., Biol Reprod 2003
:
Effects of luteinizing hormone and follicle stimulating hormone and
insulin-like growth factor-I on
aromatase activity and P450 aromatase gene expression in the ovarian follicles of red seabream, Pagrus major ... Of the growth factors used in the present study, only
IGF-I stimulated both
aromatase activity and P450arom gene expression in the ovarian fragments of red seabream ...
IGF-I slightly
enhanced the LH-induced
aromatase activity and P450arom gene expression
Ranzenigo et al., Anim Reprod Sci 2008
:
ZEA at 3,000 ng/mL inhibited FSH plus
IGF-I induced
CYP19A1 and CYP11A1 mRNA abundance
Christman et al., Fertil Steril 1991
:
The ability of hCG, human FSH, and/or
IGF-I to
induce aromatase activity was assayed by the stereospecific release of tritium from [ 1B-3H ] androstenedione ... Short-term cultures ( 72 hours ) demonstrated a marked rise in
aromatase activity in
response to human FSH and
IGF-I , whereas a smaller response to hCG was observed
Lueprasitsakul et al., Steroids 1990
:
In this tissue, the aromatase activity resides primarily in the stromal cells, and we have used cultures of stromal cells to study the
effects of insulin and
insulin-like growth factor I (IGF-I) on
aromatase activity ... However, insulin ( 100 to 1,000 microU/ml ) and
IGF-I ( 500 ng/ml ) markedly attenuated the stimulatory effect of ( Bu ) 2cAMP, but significantly
augmented the dexamethasone stimulated
aromatase activity
Mani et al., Reproduction 2010
:
IGF1 with FSH
resulted in a synergistic increase in granulosa cell number and in mRNA expression of
CYP19A1 and IGF1R without altering OE(2) production
Paul et al., Mol Cell Endocrinol 2010
:
To clarify the mechanism of 17beta-estradiol production by the ovarian follicles during vitellogenic stage of carp,
effects of
IGF-I and b-insulin either alone or in combination with HCG on
aromatase activity ( conversion of testosterone to 17beta-estradiol ) and cytochrome P450 aromatase (P450arom) gene expression were investigated in vitro ...
IGF-I and b-insulin alone
stimulated aromatase activity and P450arom gene expression and significantly enhanced HCG induced enzyme activity and P450arom gene expression
Bendell et al., Endocrinology 1990
:
EGF however inhibited FSH induced and FSH plus
IGF-I induced
aromatase activity
Spicer et al., Anim Reprod Sci 2011
:
RT-PCR measuring abundance of side-chain cleavage enzyme ( CYP11A1 ), aromatase ( CYP19A1 ), FSH receptor (FSHR) and LH receptor ( LHCGR ) mRNA in large- and small-follicle granulosa cells indicated that resistin reduced the stimulatory
effect of
IGF-I on CPY11A1 mRNA abundance in large-follicle granulosa cells but had no effect on
CYP19A1 , FSHR or LHCGR mRNA abundance in large- or small-follicle granulosa cells
Ferrari et al., Int J Oncol 1997
:
Effects of
aromatase complex selective inhibition on
insulin-like growth factor 1 and insulin-like growth factor binding protein 3 circulating levels in breast cancer ...
Effects of
aromatase complex selective inhibition on insulin-like growth factor 1 and
insulin-like growth factor binding protein 3 circulating levels in breast cancer
Sharma et al., Reproduction 2012
:
Conjugated linoleic acids attenuate FSH- and
IGF1 stimulated cell proliferation ; IGF1, GATA4, and
aromatase expression ; and estradiol-17ß production in buffalo granulosa cells involving PPAR?, PTEN, and PI3K/Akt
Reverchon et al., Fertil Steril 2013
(Infertility, Female) :
It decreases P and E2 secretion, P450scc and P450
aromatase protein levels, and IGF-IR signaling in
response to
IGF-I in primary human GCs
Erickson et al., J Clin Endocrinol Metab 1989
:
Insulin-like growth factor-I regulates
aromatase activity in human granulosa and granulosa luteal cells
Rigaudière et al., Acta Endocrinol (Copenh) 1989
:
When related to time ( 0-4 h ) and expressed as percent of control values,
aromatase activity in the
presence of insulin,
IGF-I and/or hCG exhibited a significant and transient increase at 15-30 min
Steinkampf et al., Mol Cell Endocrinol 1988
:
Effects of epidermal growth factor and
insulin-like growth factor I on the levels of mRNA encoding
aromatase cytochrome P-450 of human ovarian granulosa cells ...
Insulin-like growth factor I (IGF-I) increased
aromatase activity as well as the synthesis of P-450AROM, in a concentration dependent fashion
Nestler et al., Endocrinology 1987
:
Because pregnant diabetic women are reported to have lower serum estrogen and higher progesterone concentrations than nondiabetic pregnant women, we studied the
roles of insulin and
insulin-like growth factor I (IGF-I) in the regulation of human cytotrophoblastic
aromatase and P450 side-chain cleavage enzyme ( P450 SCC ) activities ... These studies indicate that insulin exerts a selective inhibitory effect on cytotrophoblastic aromatase activity, whereas
IGF-I inhibits
aromatase activity but stimulates P450 SCC activity
Hutchinson et al., Mol Cell Endocrinol 1988
:
IGF-I also
enhanced PMSG induced
aromatase activity and progesterone production, and accelerated their peak responses in a similar fashion to the effects observed for GH
Schteingart et al., J Steroid Biochem Mol Biol 1995
:
Regulation of Sertoli cell
aromatase activity by cell density and prolonged stimulation with FSH, EGF, insulin and
IGF-I at different moments of pubertal development
Secreto et al., Anticancer Res 1994
(Breast Neoplasms...) :
The elevated testosterone levels and the increased levels of insulin, IGF-I, and IGF-II that are seen in PCOS and abdominal obesity could favor the development of breast cancer in several ways, all of which have been demonstrated experimentally : binding of testosterone to cancer cells bearing testosterone receptors, with direct stimulation ; intratissular aromatization of testosterone to estradiol, with stimulation of estrogen-sensitive cells ; stimulation of the production of epithelial growth factor (EGF) by testosterone, with direct mitogenic effect of EGF on cancer cells ;
stimulation of
aromatase by insulin and
IGF-I ; direct mitogenic stimulation of cancer cells by insulin, IGF-I, and IGF-II ; and stimulation by IGF-I and IGF-II of the intratissular reduction of estrone to estradiol
Costrici et al., Gynecol Endocrinol 1994
:
Induction of
aromatase in human granulosa cells by both follicle stimulating hormone and
insulin-like growth factor-I involves tyrosine phosphorylation ... These findings demonstrate an involvement of a tyrosine kinase pathway in the intracellular signalling mechanism of the
IGF-I effect on
aromatase activity
Nestler et al., J Steroid Biochem Mol Biol 1993
:
Regulation of the
aromatase activity of human placental cytotrophoblasts by insulin,
insulin-like growth factor-I , and -II ... We will review studies, which show that ( i ) insulin,
insulin-like growth factor-I (IGF-I) , and -II
inhibit the
aromatase activity of human cytotrophoblasts, ( ii ) these peptides can inhibit aromatase by activation of their respective receptors, and ( iii ) the potency of IGF-II in suppressing aromatase greatly exceeds that of either insulin or IGF-I
Rappaport et al., Biol Reprod 1996
:
IGF-I inhibited
aromatase activity induced by dibutyryl cAMP and inhibited FSH stimulated estrogen production in the presence of 3-isobutyl-1-methylxanthine, suggesting that IGF-I action was independent of cAMP production ... Although
IGF-I and PMA both
inhibit aromatase induction, the independence of the IGF-I effect from PKC down-regulation suggests that the initial action of IGF-I is independent of PKC
Giudice et al., Prog Growth Factor Res 1995
(Polycystic Ovary Syndrome) :
It has been postulated that an inhibitor of
IGF 's synergistic
actions with FSH on
aromatase activity may be one ( or more ) of the IGFBPs, which contributes to the arrested state of follicular development commonly observed in this disorder
Hynes et al., J Reprod Fertil 1996
:
FSH and
IGF-I , but not EGF,
stimulated ( P < 0.01 )
aromatase activity of granulosa cells
Kudoh et al., J Steroid Biochem Mol Biol 1997
(Endometriosis) :
Inhibitory
effects of a novel
aromatase inhibitor, YM511, on growth of endometrial explants and
insulin-like growth factor-I gene expression in rats with experimental endometriosis