Gene interactions and pathways from curated databases and text-mining

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IFNG — OCLN

Text-mined interactions from Literome

Mankertz et al., J Cell Sci 2000 : Tumor necrosis factor alpha and interferon gamma diminished occludin promoter activity alone and even synergistically, suggesting a genomic regulation of alterations of the paracellular barrier
Oshima et al., Microvasc Res 2001 (Inflammatory Bowel Diseases) : In vitro, IFN-gamma also reduced endothelial barrier ( monolayer electrical resistance, increased albumin permeability ) and reduced tight junction ( occludin ) expression and staining
Minagar et al., Endothelium : journal of endothelial cell research 2003 : IFN-gamma significantly reduced occludin expression and produced gaps in endothelial monolayers ... IFN-beta 1b significantly attenuated the IFN-gamma induced decrease in occludin and VE-cadherin expression