Barreto et al., Cell Immunol 2003
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In addition, IFN-gamma induced the downregulation of surface bound HSC70 , but did not significantly alter surface bound HSP70 expression
Attia et al., Br J Haematol 2003
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By applying this method to the effect of interferon-gamma and tumour necrosis factor-alpha on normal primary CD34+ HSC , biologically significant differences could be detected, including potential mechanisms for resistance of CD34+ cells to CD95 mediated apoptosis and evidence of the differentiating effects of the cytokines
Saile et al., Eur J Cell Biol 2004
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Interferon-gamma acts proapoptotic on hepatic stellate cells (HSC) and abrogates the antiapoptotic effect of interferon-alpha by an HSP70-dependant pathway
Yang et al., J Immunol 2005
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In the present study, we used in vitro conditions promoting self renewing divisions of human HSCs to investigate the effect of IFN-gamma on HSC maintenance and function