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IFNB1 — MMP17

Text-mined interactions from Literome

Smeets et al., Arthritis Rheum 2000 (Arthritis, Rheumatoid...) : To further assess the mechanism of action, in vitro experiments were conducted to determine the effects of IFNbeta on the production of MMP-1, MMP-3 , tissue inhibitor of metalloproteinases 1 ( TIMP-1 ), and prostaglandin E2 ( PGE2 ) by human fibroblast-like synoviocytes ( FLS ) ... In addition, we measured the production of MMP-1, MMP-3 , TIMP-1, and PGE2 by RA FLS and dermal fibroblasts in the presence and absence of IFNbeta
Nelissen et al., Brain 2003 (Multiple Sclerosis) : Furthermore, the tetracycline minocycline, which has a known blocking effect in experimental autoimmune encephalomyelitis, an in vivo model of acute inflammation in multiple sclerosis, and other MMP inhibitors prevent the in vitro degradation of IFN-beta by gelatinase B