Gene interactions and pathways from curated databases and text-mining

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IFNB1 — IL2RA

Pathways - manually collected, often from reviews:

  • WikiPathways Focal Adhesion-PI3K-Akt-mTOR-signaling pathway: CSF3/EPO/IFNA7/CSH1/IFNA7/IFNA7/IFNA7/IFNA7/IFNA7/IFNA7/IFNA7/IFNA7/IFNB1/IL2/OSM/PRL/IFNA7/IFNA7 → IL3RA/IL2RB/IFNAR1/OSMR/PRLR/IL7R/IL6R/CSF3R/IL2RA/EPOR/IL4R/IL2RG/IFNAR2/GHR (activation)

Text-mined interactions from Literome

Rep et al., J Neuroimmunol 1996 : IFN-beta did not inhibit upregulations of CD40L on activated T-cells, but blocked induction of CD25 on stimulated T- and B-lymphocytes
Ferrarini et al., J Neuroimmunol 1998 (Multiple Sclerosis) : Taken all together, our findings suggest that IFNbeta1b only transiently affects CD25 expression in vivo, and that this effect can not account for the reported long lasting beneficial action of IFNbeta1b on RRMS