Kawanami et al., J Biol Chem 2009
:
Mechanistically, KLF2 promoted HIF-1alpha degradation in a von Hippel-Lindau protein independent but proteasome dependent manner
Mori et al., Mol Cancer Res 2009
(Pancreatic Neoplasms) :
In conclusion, overexpression of KLF5 in human pancreatic cancer cells is not mediated by KRAS/Raf/MAPK/Erk signaling, but involves the IL-1beta/IL-1R system, p38, and the transcription factor HIF-1alpha