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HDAC1 — ZNF217
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
ZNF217
—
HDAC1
(physical association, affinity chromatography technology)
Joshi et al., Molecular systems biology 2013
-
MIPS CORUM BHC110 complex:
BHC110 complex complex (KDM1A-GSE1-HDAC1-HDAC2-HMG20B-PHF21A-RCOR1-ZMYM2-ZNF217-ZNF516)
Lee et al., Nature 2005
-
MIPS CORUM CoREST-HDAC complex:
CoREST-HDAC complex complex (KDM1A-HDAC1-HDAC2-HMG20B-PHF21A-RCOR1-ZNF217)
You et al., Proc Natl Acad Sci U S A 2001
-
MIPS CORUM LSD1 complex:
LSD1 complex complex (KDM1A-CTBP1-HDAC1-HMG20A-HMG20B-HSPA1B-HSPA1A-PHF21A-PHF21B-RCOR1-RCOR3-RREB1-ZMYM2-ZNF217)
Shi et al., Mol Cell 2005
-
MIPS CORUM anti-BHC110 complex:
anti-BHC110 complex complex (KDM1A-GSE1-GTF2I-HDAC1-HDAC2-HMG20B-PHF21A-RCOR1-ZMYM2-ZMYM3-ZNF217)
Hakimi et al., J Biol Chem 2003
-
MIPS CORUM CtBP complex:
CtBP complex complex (KDM1A-CBX4-CDYL-CTBP1-CTBP2-EHMT1-EHMT2-HDAC1-HDAC2-LCOR-RCOR1-RCOR3-RREB1-ZEB1-ZEB2-ZNF217-ZNF516)
Shi et al., Nature 2003
-
IRef Corum Interaction:
Complex of 14 proteins
(association, affinity chromatography technology)
Shi et al., Mol Cell 2005
-
IRef Corum Interaction:
Complex of 23 proteins
(association, anti bait coimmunoprecipitation)
Hakimi et al., J Biol Chem 2003
-
IRef Corum Interaction:
Complex of 11 proteins
(association, coimmunoprecipitation)
Lee et al., Nature 2005
-
IRef Corum Interaction:
Complex of ZNF217-RCOR1-KDM1A-HMG20B-HDAC1-PHF21A-HDAC2
(association, anti bait coimmunoprecipitation)
You et al., Proc Natl Acad Sci U S A 2001
-
IRef Corum Interaction:
Complex of 18 proteins
(association, anti tag coimmunoprecipitation)
Shi et al., Nature 2003
-
IRef Intact Interaction:
Complex of 92 proteins
(association, anti tag coimmunoprecipitation)
Joshi et al., Molecular systems biology 2013
-
IRef Intact Interaction:
Complex of 47 proteins
(association, anti tag coimmunoprecipitation)
Joshi et al., Molecular systems biology 2013
-
STRING interaction:
ZNF217
—
HDAC1
(interaction, mapped from grid)
-
STRING interaction:
HDAC1
—
ZNF217
(interaction, mapped from grid kegg_pathways mint intact dip)
Text-mined interactions from Literome
Kliebenstein et al., Mol Plant Microbe Interact 1999
:
LSD1 regulates salicylic acid induction of copper zinc
superoxide dismutase in Arabidopsis thaliana
Koipally et al., J Biol Chem 2000
:
These data strongly suggest that
CtBP contributes to a
histone deacetylase activity independent mechanism of repression by Ikaros
Brunori et al., J Virol 2001
(Neoplasms) :
Tcf4 is constitutively activated by mutations in the adenomatous polyposis coli and beta-catenin genes in virtually all colon tumors and is constitutively
repressed by Groucho and
CtBP in normal tissue
Izutsu et al., Blood 2001
(Cell Transformation, Neoplastic...) :
The corepressor
CtBP interacts with Evi-1 to
repress transforming growth factor beta signaling
Vo et al., Mol Cell Biol 2001
:
In this study, we show that the interaction between
CtBP and the nuclear hormone receptor corepressor RIP140 is
regulated similarly, in this case by
p300/CBP itself
Izutsu et al., Oncogene 2002
(Leukemia, Myeloid) :
Here, we demonstrate that AML1/Evi-1 interacts with CtBP in SKH1 cells, a leukemic cell line which endogenously overexpresses AML1/Evi-1 and that
AML1/Evi-1 requires the interaction with
CtBP to repress AML1 induced transactivation ... Here, we demonstrate that AML1/Evi-1 interacts with CtBP in SKH1 cells, a leukemic cell line which endogenously overexpresses AML1/Evi-1 and that
AML1/Evi-1 requires the interaction with
CtBP to repress AML1 induced transactivation
Atchison et al., EMBO J 2003
:
Finally, we found that
YY1 , as well as Polycomb,
required the co-repressor protein
CtBP for repression in vivo
Barnes et al., Nat Struct Biol 2003
:
We describe here the binding, phosphorylation and functional
regulation of
CtBP by the
p21 activated kinase 1 (Pak1) ... In the presence of NADH,
Pak1 superphosphorylates CtBP and
inhibits CtBP dehydrogenase activity, suggesting that preferential phosphorylation of active CtBP may alter secondary structures and influence both enzymatic and corepressor functions ...
Pak1 regulation of
CtBP represents a new model of corepressor regulation whereby cellular signaling cascades may influence gene expression in mammalian cells
Zhang et al., Cell 2003
:
Expression of
HIPK2 or exposure to UV irradiation
reduced CtBP levels via a proteosome mediated pathway
Srinivasan et al., Genes Dev 2004
:
These results reveal a new
role for
CtBP in controlling
YY1 DNA binding and recruitment of PcG proteins to DNA
Alpatov et al., Mol Cell Biol 2004
:
Nuclear speckle associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves
CtBP mediated repression of the
E-cadherin gene
Chan et al., Blood 2005
(Myelodysplastic Syndromes...) :
These results suggest a central
role for
CtBP in
AML1-FOG2 transcriptional repression and implicate coordinated disruption of the AML1 and GATAdevelopmental programs in the pathogenesis of myelodysplasia ... These results suggest a central
role for
CtBP in
AML1-FOG2 transcriptional repression and implicate coordinated disruption of the AML1 and GATAdevelopmental programs in the pathogenesis of myelodysplasia
Zhang et al., Proc Natl Acad Sci U S A 2005
:
Homeodomain interacting protein kinase-2 mediates
CtBP phosphorylation and degradation in UV-triggered apoptosis
Paliwal et al., Mol Cell Biol 2006
(Colonic Neoplasms) :
Interaction with
ARF resulted in proteasome dependent
CtBP degradation ... Both
ARF induced CtBP degradation and
CtBP small interfering RNA led to p53 independent apoptosis in colon cancer cells ...
ARF induction of apoptosis was
dependent on its ability to interact with
CtBP , and reversal of ARF induced CtBP depletion by CtBP overexpression abrogated ARF induced apoptosis
Sierra et al., Genes Dev 2006
:
We conclude that, in addition to regulating the stability of beta-cat, APC facilitates
CtBP mediated repression of
Wnt target genes in normal, but not in colorectal cancer cells
Wang et al., J Biol Chem 2006
:
Previously, we have identified the homeodomain interacting protein kinase 2 as such a regulator and demonstrated that
HIPK2 activation
causes Ser-422 phosphorylation and degradation of
CtBP ... In this study, we found that
c-Jun NH2-terminal kinase 1 activation
triggered CtBP phosphorylation on Ser-422 and subsequent degradation, inducing p53 independent apoptosis in human lung cancer cells
Huang et al., Nature 2007
:
p53 is
regulated by the lysine demethylase
LSD1
Arrese et al., Arch Biochem Biophys 2008
:
Using lipoprotein complexes containing triolein it is shown that
PKA mediated phosphorylation of
Lsd1 promoted a 1.7-fold activation of the main fat body lipase demonstrating the direct link between Lsd1 phosphorylation and activation of lipolysis
Oikawa et al., J Biol Chem 2008
:
As
CtBP is reportedly
involved in p53 independent
programmed cell death , we examine here whether CIBZ is associated with apoptosis
Gocke et al., PloS one 2008
:
ZNF198 stabilizes the
LSD1-CoREST-HDAC1 complex on chromatin through its MYM-type zinc fingers
Wang et al., Nat Genet 2009
:
Our findings suggest that
LSD1 demethylates and
stabilizes Dnmt1 , thus providing a previously unknown mechanistic link between the histone and DNA methylation systems
Yang et al., J Mol Biol 2009
:
Over-expression of
CtBP potentiated the trans-repressive activity of
HDGF ; on the other hand, knocking down CtBP attenuated the trans-repressive effect of HDGF ... Finally, fluorescent microscopy showed that
HDGF induced the nuclear accumulation of
CtBP , suggesting that HDGF forms a transcriptional complex with CtBP
Haga et al., EMBO J 2009
:
Finally,
CtBP1/BARS activated
PLD1 in a synergistic manner with other PLD activators, including ADP-ribosylation factors as demonstrated by in vitro and intact cell systems
Kovi et al., Cell Death Differ 2010
:
Expression profiling of BH3-only gene expression in ARF expressing or CtBP-deficient cells revealed that
Bik was uniquely
regulated by
ARF/CtBP in colon cancer cells, whereas additional BH3-only proteins ( Bim, Bmf ) showed CtBP dependent repression in osteosarcoma cells
Neufeld et al., Adv Exp Med Biol 2009
(Colorectal Neoplasms) :
This down-regulation of nuclear
beta-catenin activity by APC most likely
involves nuclear sequestration of beta-catenin from the transcription complex as well as interaction of APC with transcription corepressor
CtBP
Lv et al., Eur J Cell Biol 2010
:
LSD1 positively
regulates the BUBR1 and
MAD2 promoter activity and maintains local monomethylation status of H3K9, which is a repressive histone mark for gene transcription
Amente et al., Oncogene 2010
:
In addition, we demonstrate that Myc binds and recruits
LSD1 to the E-box chromatin and the formation of this complex is
stimulated by
cAMP-PKA
Skalska et al., PLoS Pathog 2010
(Epstein-Barr Virus Infections) :
Epigenetic repression of
p16(INK4A) by latent Epstein-Barr virus
requires the interaction of EBNA3A and EBNA3C with
CtBP ... These novel LCLs have revealed that the chromatin remodelling and epigenetic repression of
p16(INK4A) requires the interaction of both EBNA3A and EBNA3C with
CtBP
Lin et al., Oncogene 2010
:
In the absence of
LSD1 , Snai1 fails to
repress E-cadherin
Madison et al., Oncogene 2010
:
PARP inhibition attenuated activation of p21 transcription by both p53 independent and p53 dependent processes, in a
CtBP dependent manner ... PARP inhibition attenuated activation of
p21 transcription by both p53 independent and p53 dependent processes, in a
CtBP dependent manner
Di et al., Nature structural & molecular biology 2010
:
Loss of
CtBP from the BRCA1 promoter through estrogen induction, depletion by RNA interference or increased NAD+/NADH ratio leads to HDAC1 dismissal, elevated histone acetylation and
increased BRCA1 transcription
Urvalek et al., American journal of translational research 2011
:
Interestingly,
CtBP promoted sumoylation at K67 of wild-type but not AVALF mutant KLF8, and
KLF8 interaction with CtBP was
inhibited by treatment with the HDAC inhibitors, ectopic expression of the co-activators, or K93Q or K95Q mutation
Huang et al., Breast Cancer Res Treat 2012
(Breast Neoplasms) :
We also demonstrated that inhibition of
LSD1 activity by a pharmacological inhibitor, pargyline, or siRNA
resulted in increased
acetylation of H3K9 (AcH3K9)
Mulligan et al., Mol Cell 2011
:
A
SIRT1-LSD1 corepressor complex
regulates Notch target gene expression and development
Le Douce et al., Nucleic Acids Res 2012
:
In the present work, we report that the histone demethylase
LSD1 represses
HIV-1 transcription and viral expression in a synergistic manner with CTIP2
Rajabi et al., J Biol Chem 2012
(Breast Neoplasms) :
MUC1-C blocks the interaction between TCF7L2 and the
C-terminal binding protein (CtBP) , a suppressor of TCF7L2 mediated transcription
Cai et al., PloS one 2012
(Spinal Cord Injuries) :
Taken together, it is suggested that : ( i ) in the
presence of
CtBP , CIBZ gene is involved in secondary injury process and trigger the activation of apoptotic
caspase-3 and bax genes independent of p53 ; ( ii ) abrupt down-regulation of CtBP at 8 h is a sign of mitochondria dysfunction and the onset of cell death ; ( iii ) it could be used as an inhibitor or target drug of caspase-3 gene to improve spinal cord function
Yu et al., Biochem Biophys Res Commun 2012
(Breast Neoplasms) :
The histone demethylase
LSD1 is
required for estrogen dependent
S100A7 gene expression in human breast cancer cells ... Our data showed in vivo association of LSD1 with S100A7 promoters, confirming the potential
role of
LSD1 in regulating
S100A7 expression ... Together, our data suggest that estrogen induced
S100A7 expression
mediated by the histone demethylase
LSD1 may downregulate breast cancer cell proliferation, implying a potential tumor suppressor-like function for S100A7
Zhong et al., Invest Ophthalmol Vis Sci 2013
(Diabetes Mellitus, Experimental...) :
Regulation of
LSD1 by LSD1-siRNA ameliorated glucose induced decrease in H3K4 methylation at Sod2, and
prevented decrease in
Sod2 gene expression
Paliwal et al., Genes & cancer 2012
:
We noted a strict positive correlation between CtBP2 and Tiam1 expression levels and that CtBP promotion of cell migration required
CtBP dependent transcriptional activation of
Tiam1 ... An analysis of the Tiam1 promoter revealed binding sites for the CtBP interacting Kruppel-like factor 8 (KLF8), and a Tiam1 promoter luciferase reporter was induced in the presence of both KLF8 and CtBP2, consistent with
KLF8 dependent
CtBP transactivation of Tiam1
Vasilatos et al., Carcinogenesis 2013
(Breast Neoplasms) :
Taken together, these results provide novel mechanistic insight into the breast cancer subtype dependent
role of
LSD1 in mediating
HDAC activity and therapeutic efficacy of HDAC inhibitor
Kashyap et al., Mol Oncol 2013
:
We show that functional depletion of
LSD1 expression using siRNA in prostate cancer cells decreases VEGF-A and
blocks androgen induced VEGF-A, PSA and
Tmprss2 expression ... We show that functional depletion of
LSD1 expression using siRNA in prostate cancer cells decreases VEGF-A and
blocks androgen induced
VEGF-A , PSA and Tmprss2 expression ... We show that functional depletion of
LSD1 expression using siRNA in prostate cancer cells decreases VEGF-A and
blocks androgen induced VEGF-A,
PSA and Tmprss2 expression
Zhong et al., Diabetes 2013
(Diabetes Mellitus, Experimental...) :
The
role of
LSD1 in
MMP-9 activation was investigated in isolated retinal endothelial cells transfected with LSD1 small interfering RNA ( siRNA )
Ombra et al., Biochim Biophys Acta 2013
(Breast Neoplasms...) :
Retinoic acid impairs estrogen signaling in breast cancer cells by interfering with
activation of
LSD1 via
PKA
Sollerbrant et al., Nucleic Acids Res 1996
(Cell Transformation, Neoplastic) :
This might suggest that
CtBP binding can
regulate E1A mediated transformation by modulating
CR1 dependent control of transcription
Yu et al., J Biol Chem 1998
:
This finding suggests that
BRCA1 regulates gene expression, at least in part, by modulating
CtBP mediated transcriptional repression