◀ Back to GRP
GRP — GRPR
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
O/k complex ()
→
Complex of GRP-GRPR
(increases, GRP/GRPR Activity)
Levine et al., Cancer Res 2003*
Evidence: We show that BBS treatment induced inhibitor of NF kappa B degradation, NF kappa B translocation to the cell nucleus, increased NF kappa B binding to its DNA consensus sequence
-
Reactome Reaction:
GRPR
→
GRP
(direct_complex)
Corjay et al., J Biol Chem 1991*, Fathi et al., J Biol Chem 1993*
-
Reactome Reaction:
GRPR
→
GRP
(reaction)
Rubio et al., Genomics 1999, Corjay et al., J Biol Chem 1991*, Dowal et al., J Biol Chem 2006, Lambert et al., Science signaling 2008, Amatruda et al., Proc Natl Acad Sci U S A 1991, Ferguson et al., J Biol Chem 1986, Fathi et al., J Biol Chem 1993*, Chen et al., Biochim Biophys Acta 1996
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Thomas et al., Neoplasia (New York, N.Y.) 2005
(Carcinoma, Non-Small-Cell Lung...) :
EGF and
GRP both stimulated NSCLC proliferation, and inhibition of either EGFR or
GRPR resulted in cell death
Ashour et al., Am J Respir Crit Care Med 2006
(Pulmonary Fibrosis) :
GRPR appears to
mediate all effects of
GRP , but only part of the bombesin effect on alveolarization, suggesting that novel receptors may mediate some effects of bombesin in newborn lung
Baldwin et al., Regul Pept 2007
:
The many biological activities of the hormone
gastrin releasing peptide (GRP) , including stimulation of acid secretion and of tumour growth, are
mediated by the
gastrin releasing peptide receptor ( GRP-R )
Zhou et al., Proc Natl Acad Sci U S A 2011
(Asthma) :
GRP blockade
diminished serine phosphorylation of
GRPR with ozone or OVA