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GNAZ — S1PR1

Pathways - manually collected, often from reviews:

• NCI Pathway Database S1P1 pathway: Erk1-2 (MAPK3/MAPK1) → S1P1/S1P/Gi complex (S1PR1-GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1) (modification, collaborate)
  Van Brocklyn et al., Cancer Lett 2002
  Evidence: mutant phenotype, assay
• NCI Pathway Database S1P1 pathway: S1P1/S1P/Gi complex (S1PR1-GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1) → Erk1-2-active (MAPK3/MAPK1) (modification, activates)
  Van Brocklyn et al., Cancer Lett 2002
  Evidence: mutant phenotype, assay
• NCI Pathway Database S1P1 pathway: S1P1/S1P/Gi complex (S1PR1-GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1) → S1P1/S1P complex (S1PR1) (modification, collaborate) Van Brocklyn et al., J Cell Biol 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database S1P1 pathway: S1P1/S1P/Gi complex (S1PR1-GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1) → Gi family (GNAI2/GNAI3/GNAO1/GNAO1/GNAZ/GNAI1) (modification, collaborate)
  Van Brocklyn et al., J Cell Biol 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database S1P1 pathway: S1P1/S1P complex (S1PR1) → Gi family (GNAI2/GNAI3/GNAO1/GNAO1/GNAZ/GNAI1) (modification, collaborate)
  Van Brocklyn et al., J Cell Biol 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database S1P1 pathway: S1P1/S1P/Gi complex (S1PR1-GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1) → PLCgamma1 (PLCG1) (modification, activates)
• NCI Pathway Database S1P3 pathway: S1P1/S1P/Gi complex (S1PR1-GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1) → S1P/S1P2/Gi complex (S1PR2-GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1) (angiogenesis, collaborate)
  Kono et al., J Biol Chem 2004
  Evidence: mutant phenotype, assay
• NCI Pathway Database S1P3 pathway: S1P1/S1P/Gi complex (S1PR1-GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1) → S1P/S1P3/Gi complex (S1PR3-GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1) (angiogenesis, collaborate)
  Kono et al., J Biol Chem 2004
  Evidence: mutant phenotype, assay