UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to GNA15

EDN1 — GNA15

Pathways - manually collected, often from reviews:

NCI Pathway Database Endothelins: None → ETB receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1) (modification, collaborate)
Aramori et al., J Biol Chem 1992, Takuwa et al., Am J Physiol 1989, Resink et al., Biochem Biophys Res Commun 1988
Evidence: assay, other species
NCI Pathway Database Endothelins: ETB receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1) (modification, activates) Aramori et al., J Biol Chem 1992, Takuwa et al., Am J Physiol 1989, Resink et al., Biochem Biophys Res Commun 1988
Evidence: assay, other species
NCI Pathway Database Endothelins: ETB receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1) → None (modification, activates) Aramori et al., J Biol Chem 1992, Takuwa et al., Am J Physiol 1989, Resink et al., Biochem Biophys Res Commun 1988
Evidence: assay, other species
NCI Pathway Database Endothelins: ETA receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRA-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1) → PLC beta (PLCB3/PLCB2/PLCB1) (modification, collaborate)
Aramori et al., J Biol Chem 1992
NCI Pathway Database Endothelins: ETA receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRA-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1) → ETA receptor/Endothelin-1/Gq/GTP complex (EDNRA-EDN1-GNA11_GNAQ_GNA15_GNA14) (modification, collaborate)
Aramori et al., J Biol Chem 1992
NCI Pathway Database Endothelins: PLC beta (PLCB3/PLCB2/PLCB1) → ETA receptor/Endothelin-1/Gq/GTP complex (EDNRA-EDN1-GNA11_GNAQ_GNA15_GNA14) (modification, collaborate)
Aramori et al., J Biol Chem 1992
NCI Pathway Database Endothelins: ETA receptor/Endothelin-1 complex (EDNRA-EDN1) → Gq family/GDP complex (GNA11_GNAQ_GNA15_GNA14) (modification, collaborate)
Aramori et al., J Biol Chem 1992
NCI Pathway Database Endothelins: ETA receptor/Endothelin-1 complex (EDNRA-EDN1) → ETA receptor/Endothelin-1/Gq/GTP complex (EDNRA-EDN1-GNA11_GNAQ_GNA15_GNA14) (modification, collaborate)
Aramori et al., J Biol Chem 1992
NCI Pathway Database Endothelins: Gq family/GDP complex (GNA11_GNAQ_GNA15_GNA14) → ETA receptor/Endothelin-1/Gq/GTP complex (EDNRA-EDN1-GNA11_GNAQ_GNA15_GNA14) (modification, collaborate)
Aramori et al., J Biol Chem 1992
NCI Pathway Database Endothelins: None → ETA receptor/Endothelin-1/Gq/GTP complex (EDNRA-EDN1-GNA11_GNAQ_GNA15_GNA14) (modification, collaborate)
Aramori et al., J Biol Chem 1992
NCI Pathway Database Endothelins: ETA receptor/Endothelin-1/Gq/GTP complex (EDNRA-EDN1-GNA11_GNAQ_GNA15_GNA14) → None (modification, collaborate) Aramori et al., J Biol Chem 1992
NCI Pathway Database Endothelins: None → ETA receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRA-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1) (modification, collaborate)
Aramori et al., J Biol Chem 1992, Takuwa et al., Am J Physiol 1989, Resink et al., Biochem Biophys Res Commun 1988
Evidence: assay, other species
NCI Pathway Database Endothelins: ETA receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRA-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1) → None (modification, activates) Aramori et al., J Biol Chem 1992, Takuwa et al., Am J Physiol 1989, Resink et al., Biochem Biophys Res Commun 1988
Evidence: assay, other species
NCI Pathway Database Endothelins: ETB receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1) → p38 alpha (MAPK14) (modification, activates) Aquilla et al., J Biol Chem 1996
Evidence: mutant phenotype, other species
NCI Pathway Database Endothelins: Gq family/GDP complex (GNA11_GNAQ_GNA15_GNA14) → ETB receptor/Endothelin-1 complex (EDNRB-EDN1) (modification, collaborate)
Aramori et al., J Biol Chem 1992
NCI Pathway Database Endothelins: Gq family/GDP complex (GNA11_GNAQ_GNA15_GNA14) → ETB receptor/Endothelin-1/Gq/GTP complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14) (modification, collaborate)
Aramori et al., J Biol Chem 1992
NCI Pathway Database Endothelins: None → ETB receptor/Endothelin-1/Gq/GTP complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14) (modification, collaborate)
Aramori et al., J Biol Chem 1992
NCI Pathway Database Endothelins: ETB receptor/Endothelin-1 complex (EDNRB-EDN1) → ETB receptor/Endothelin-1/Gq/GTP complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14) (modification, collaborate)
Aramori et al., J Biol Chem 1992
NCI Pathway Database Endothelins: ETB receptor/Endothelin-1/Gq/GTP complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14) → None (modification, collaborate) Aramori et al., J Biol Chem 1992
NCI Pathway Database Endothelins: ETB receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1) → PLC beta (PLCB3/PLCB2/PLCB1) (modification, collaborate)
Aramori et al., J Biol Chem 1992
NCI Pathway Database Endothelins: ETB receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1) → ETB receptor/Endothelin-1/Gq/GTP complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14) (modification, collaborate)
Aramori et al., J Biol Chem 1992
NCI Pathway Database Endothelins: PLC beta (PLCB3/PLCB2/PLCB1) → ETB receptor/Endothelin-1/Gq/GTP complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14) (modification, collaborate)
Aramori et al., J Biol Chem 1992
Reactome Reaction: EDN1 → GNA15 (indirect_complex) Rubio et al., Genomics 1999, Dowal et al., J Biol Chem 2006, Amatruda et al., Proc Natl Acad Sci U S A 1991, Ferguson et al., J Biol Chem 1986, Chen et al., Biochim Biophys Acta 1996
Reactome Reaction: EDN1 → GNA15 (reaction) Rubio et al., Genomics 1999, Dowal et al., J Biol Chem 2006, Lambert et al., Science signaling 2008, Amatruda et al., Proc Natl Acad Sci U S A 1991, Ferguson et al., J Biol Chem 1986, Chen et al., Biochim Biophys Acta 1996