Gene interactions and pathways from curated databases and text-mining

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GATA1 — RBBP4

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Matsuoka et al., Eur J Pharmacol 2007 (Thrombocytopenia) : Here, we report that GATA-1 and 10 haematopoietic factors ( SCL, NF-E2, EKLF, Pleckstrin, Thrombin-R, LMO2, PU.1, Fli-1, AML1, and TCF11 ) are transcriptionally repressed by HDAC inhibitors in a similar pattern ( R > 0.98 ), and putative GATA-1 binding sites are found in almost all promoters of these genes ... Further, this report also asserts that HDAC inhibitor increases megakaryocyte counts and inhibits GATA-1 gene expression in rat spleen ... Together, these results suggest that HDAC inhibitors inhibit GATA-1 gene expression by decreasing the transactivation function of GATA-1 itself, and that this may in turn lead to a delay in megakaryocyte maturation and finally cause thrombocytopenia
Matsuoka et al., Biol Pharm Bull 2008 (Thrombocytopenia) : In addition to its immunosuppressive activity, HDAC inhibitors block GATA binding protein-1 (GATA-1) gene expression in megakaryocytes and elicit thrombocytopenia