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GATA1 — RBBP4
Pathways - manually collected, often from reviews:
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NCI Pathway Database Signaling events mediated by HDAC Class I:
GATA1/Fog1 complex (GATA1-ZFPM1)
→
NuRD/MBD3 Complex complex (MTA2-MBD3-CHD3-CHD4-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, collaborate)
Hong et al., EMBO J 2005, Rodriguez et al., EMBO J 2005
Evidence: assay, physical interaction, other species
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
GATA1/Fog1 complex (GATA1-ZFPM1)
→
NuRD/MBD3 Complex/GATA1/Fog1 complex (MTA2-MBD3-CHD3-CHD4-GATAD2A-GATAD2B-GATA1-ZFPM1-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, collaborate)
Hong et al., EMBO J 2005, Rodriguez et al., EMBO J 2005
Evidence: assay, physical interaction, other species
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
NuRD/MBD3 Complex complex (MTA2-MBD3-CHD3-CHD4-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
→
NuRD/MBD3 Complex/GATA1/Fog1 complex (MTA2-MBD3-CHD3-CHD4-GATAD2A-GATAD2B-GATA1-ZFPM1-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, collaborate)
Hong et al., EMBO J 2005, Rodriguez et al., EMBO J 2005
Evidence: assay, physical interaction, other species
Text-mined interactions from Literome
Matsuoka et al., Eur J Pharmacol 2007
(Thrombocytopenia) :
Here, we report that
GATA-1 and 10 haematopoietic factors ( SCL, NF-E2, EKLF, Pleckstrin, Thrombin-R, LMO2, PU.1, Fli-1, AML1, and TCF11 ) are transcriptionally
repressed by
HDAC inhibitors in a similar pattern ( R > 0.98 ), and putative GATA-1 binding sites are found in almost all promoters of these genes ... Further, this report also asserts that
HDAC inhibitor increases megakaryocyte counts and
inhibits GATA-1 gene expression in rat spleen ... Together, these results suggest that
HDAC inhibitors
inhibit GATA-1 gene expression by decreasing the transactivation function of GATA-1 itself, and that this may in turn lead to a delay in megakaryocyte maturation and finally cause thrombocytopenia
Matsuoka et al., Biol Pharm Bull 2008
(Thrombocytopenia) :
In addition to its immunosuppressive activity,
HDAC inhibitors
block GATA binding protein-1 (GATA-1) gene expression in megakaryocytes and elicit thrombocytopenia