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CCNB1 — FOXM1

Pathways - manually collected, often from reviews:

• NCI Pathway Database FOXM1 transcription factor network: FOXM1 (FOXM1) → Cyclin B1 (CCNB1) (transcription, activates) Leung et al., FEBS Lett 2001*, Krupczak-Hollis et al., Dev Biol 2004*, Laoukili et al., Nat Cell Biol 2005*, Ma et al., J Cell Sci 2005*
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database FOXM1 transcription factor network: FOXM1C (FOXM1) → Cyclin B1 (CCNB1) (transcription, activates) Leung et al., FEBS Lett 2001*, Krupczak-Hollis et al., Dev Biol 2004*, Laoukili et al., Nat Cell Biol 2005*, Ma et al., J Cell Sci 2005*
  Evidence: mutant phenotype, reporter gene, physical interaction
• Reactome Reaction: FOXM1 → CCNB1 (reaction) Major et al., Mol Cell Biol 2004, Laoukili et al., Mol Cell Biol 2008*, Fu et al., Nat Cell Biol 2008*

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CCNB1 — FOXM1 (physical association, affinity chromatography technology) Major et al., Mol Cell Biol 2004
• IRef Innatedb Interaction: CCNB1 — FOXM1 (unknown, -) Major et al., Mol Cell Biol 2004

Text-mined interactions from Literome

Leung et al., FEBS Lett 2001 : Quantitation of cyclin B1 and D1 levels using flow cytometric, Western and Northern analyses reveals that elevated FoxM1 levels lead to stimulation of cyclin B1 but not cyclin D1 expression ... Transient reporter assays in the dox-inducible lines and upon co-transfection with a constitutive FoxM1 expression plasmid suggest that FoxM1 can activate the cyclin B1 promoter
Park et al., Hepatology 2008 (Carcinoma, Hepatocellular...) : At the mechanistic level, TIS21 inhibited FoxM1 phosphorylation, a required modification for its activation, by reducing cyclin B1-cdk1 activity, examined by in vitro kinase assay and FoxM1 mutant analyses