Gene interactions and pathways from curated databases and text-mining

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FOS — STAT5A

Pathways - manually collected, often from reviews:

  • BioCarta il 3 signaling pathway: STAT5/STAT5 complex (STAT5A_STAT5B) → c-FOS (FOS) (modification, activates)

Text-mined interactions from Literome

García-Lora et al., Cancer Immunol Immunother 2001 : Here we report that PSK enhanced AP-1 and CRE binding activities, whereas IL-2 increased AP-1 and SP-1 and modified GAS/ISRE, IRF-1 and STAT5
Domínguez-Cáceres et al., Oncogene 2004 : However, it did not modify PRL stimulation of c-Fos mRNA expression or activation of Erk1/2 and Stat5
Gutzman et al., Oncogene 2007 (Neoplasms) : Stat5 activation inhibits prolactin induced AP-1 activity : distinct prolactin initiated signals in tumorigenesis dependent on cell context
Bergelson et al., J Biol Chem 1998 : We also show that AP-1 activation does not require maximal STAT5 activation and may occur via a STAT5 independent signaling pathway