Gene interactions and pathways from curated databases and text-mining

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FOS — NPPA

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Kiemer et al., J Immunol 2000 : Besides the known inhibition of NF-kappaB activation, in this study we demonstrated that ANP also attenuates the activation of the proinflammatory transcription factor AP-1 ( gel shift assay )
Kiemer et al., J Hepatol 2000 (Ischemia...) : ANP markedly reduced binding activities of both forms of AP-1 ... 8-Br-cGMP mimicked the effects of ANP on NF-kappaB and AP-1
Moriyama et al., Biochem Biophys Res Commun 2006 : ANP inhibits LPS induced stimulation of rat microglial cells by suppressing NF-kappaB and AP-1 activations ... NF-kappaB and AP-1 activities were enhanced in LPS stimulated microglial cells, and these enhancements were significantly suppressed by ANP ( 10 ( -6 ) M )
Itoh et al., Biochem Biophys Res Commun 1991 : However, the chloramphenicol acetyl transferase (CAT) assay using a CAT expression vector containing the AP-1 binding element showed that ANP had no effect on the basal and PMA stimulated AP-1 activity in transfected RASM cells