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FLT1 — NRP1

Pathways - manually collected, often from reviews:

• NCI Pathway Database VEGFR1 specific signals: VEGFR1 homodimer/NRP1 complex (FLT1-NRP1) → VEGFR1 homodimer complex (FLT1) (modification, collaborate)
  Fuh et al., J Biol Chem 2000*, Gluzman-Poltorak et al., J Biol Chem 2001*
  Evidence: physical interaction
• NCI Pathway Database VEGFR1 specific signals: VEGFR1 homodimer/NRP1 complex (FLT1-NRP1) → NRP1 (NRP1) (modification, collaborate) Fuh et al., J Biol Chem 2000*, Gluzman-Poltorak et al., J Biol Chem 2001*
  Evidence: physical interaction
• NCI Pathway Database VEGFR1 specific signals: VEGFR1 homodimer complex (FLT1) → NRP1 (NRP1) (modification, collaborate) Fuh et al., J Biol Chem 2000*, Gluzman-Poltorak et al., J Biol Chem 2001*
  Evidence: physical interaction
• NCI Pathway Database VEGFR1 specific signals: VEGFR1 homodimer/NRP1/VEGFR 121 complex (FLT1-NRP1-VEGFA) → VEGFR1 homodimer/NRP1 complex (FLT1-NRP1) (modification, collaborate)
  Mamluk et al., J Biol Chem 2002
  Evidence: physical interaction
• NCI Pathway Database VEGFR1 specific signals: VEGFR1 homodimer/NRP1/VEGFR 121 complex (FLT1-NRP1-VEGFA) → VEGFA121 (VEGFA) (modification, collaborate) Mamluk et al., J Biol Chem 2002
  Evidence: physical interaction
• NCI Pathway Database VEGFR1 specific signals: VEGFR1 homodimer/NRP1 complex (FLT1-NRP1) → VEGFA121 (VEGFA) (modification, collaborate) Mamluk et al., J Biol Chem 2002
  Evidence: physical interaction
• NCI Pathway Database VEGF and VEGFR signaling network: VEGFR1 (dimer)/VEGFA (dimer)/NRP1 complex (FLT1-VEGFA-NRP1) → VEGFA (dimer) complex (VEGFA) (modification, collaborate)
  Fuh et al., J Biol Chem 2000*, Banerjee et al., Biochemistry 2008*, Kawamura et al., Blood 2008*
  Evidence: physical interaction
• NCI Pathway Database VEGF and VEGFR signaling network: VEGFR1 (dimer)/VEGFA (dimer)/NRP1 complex (FLT1-VEGFA-NRP1) → NRP1 (NRP1) (modification, collaborate) Fuh et al., J Biol Chem 2000*, Banerjee et al., Biochemistry 2008*, Kawamura et al., Blood 2008*
  Evidence: physical interaction
• NCI Pathway Database VEGF and VEGFR signaling network: VEGFR1 (dimer)/VEGFA (dimer)/NRP1 complex (FLT1-VEGFA-NRP1) → VEGFR1 (FLT1) (modification, collaborate) Fuh et al., J Biol Chem 2000*, Banerjee et al., Biochemistry 2008*, Kawamura et al., Blood 2008*
  Evidence: physical interaction
• NCI Pathway Database VEGF and VEGFR signaling network: NRP1 (NRP1) → VEGFR1 (FLT1) (modification, collaborate) Fuh et al., J Biol Chem 2000*, Banerjee et al., Biochemistry 2008*, Kawamura et al., Blood 2008*
  Evidence: physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: FLT1 — NRP1 (in vitro) Fuh et al., J Biol Chem 2000*
• IRef Intact Interaction: FLT1 — NRP1 (physical association, anti bait coimmunoprecipitation) Snuderl et al., Cell 2013*

Text-mined interactions from Literome

Gustafsson et al., J Appl Physiol 2005 (Reperfusion Injury) : VEGFR-1 mRNA expression increased 2 h after exercise, and neuropilin-1 expression was transiently reduced , while all three receptors increased by 6 h
Onofri et al., J Endocrinol 2006 (Adenoma...) : In normal pituitaries, VEGFR-1 was detected in endocrine cells, whereas VEGFR-2 and NRP-1 were exclusively expressed in endothelial cells