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AKT2 — FASLG

Text-mined interactions from Literome

Suhara et al., Mol Cell Biol 2002 : Suppression of Akt signaling induces Fas ligand expression : involvement of caspase and Jun kinase activation in Akt mediated Fas ligand regulation ... Suppression of Akt signaling increased the activity of c-Jun N-terminal kinase, and transduction of dominant negative c-Jun inhibited FasL induction under these conditions ... Diminished Akt signaling promoted the cleavage of caspase 3, and both caspase 3 cleavage and FasL induction were inhibited by transduction of dominant negative caspase 9 or the caspase 8 inhibitor CrmA
Uriarte et al., Cell Death Differ 2005 : In T lymphocytes, the role of Akt in regulating Fas/Fas ligand (FasL) mediated apoptotic signaling and death is not clearly understood
Lu et al., J Immunol 2006 : In this study, we show that stimulation of the Fas receptor by its ligand (FasL) induces rapid phosphorylation of Akt/PKB and a parallel increase in cell apoptosis in epidermal Cl41 cells ... Treatment of the cells with pharmacological inhibitors of PI3K, wortmannin and 2- ( 4-morpholinyl ) -8-phenyl-4H-1-benzopyran-4-1 ( LY294002 ), similarly inhibits FasL induced apoptosis and Akt/PKB phosphorylation, indicating that PI3K is an upstream mediator of Akt/PKB and is involved in Fas mediated cell death ... Electron spin resonance studies show that FasL treatment induces rapid generation of reactive oxygen species, and inhibition of ROS by antioxidants effectively inhibits Akt/PKB signaling, suggesting that FasL activation of Akt/PKB is redox sensitive
Selvendiran et al., J Biol Chem 2007 (Ovarian Neoplasms) : Within 12 h, EF24 induced a membranous FasL expression, consistent with a substantial decrease in the Ser ( 473 ) and Thr ( 308 ) phosphorylation of Akt , a known negative regulator of FasL transcription
Subramanyam et al., J Biol Chem 2010 : Staurosporine, tumor necrosis factor-alpha, or a Fas ligand inhibited both RVI and hypertonicity induced Akt activation in a manner sensitive to a scavenger for reactive oxygen species ( ROS )
Lokeshwar et al., Cancer Res 2010 (Neoplasm Invasiveness...) : 4-MU induced caspase-8, caspase-9, and caspase-3 activation, PARP cleavage, upregulation of Fas-L , Fas, FADD and DR4, and downregulation of bcl-2, phosphorylated bad, bcl-XL, phosphorylated Akt , phosphorylated IKB, phosphorylated ErbB2, and phosphorylated epidermal growth factor receptor
Casado-Zapico et al., J Pineal Res 2011 (Leukemia) : The cytotoxic effect and the increase in Fas and Fas L were dependent on Akt activation
Iyer et al., J Immunol 2011 : We demonstrate using both human renal epithelial 293T cells and Jurkat T-lymphocyte cells that although FasL activates both Akt and NF-?B, Akt inhibits FasL dependent NF-?B activity in a reactive oxygen species dependent manner