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CDKN1A — ERBB2
Text-mined interactions from Literome
Tan et al., Mol Cell 2002
(Breast Neoplasms) :
One mechanism is via
ErbB2 mediated upregulation of
p21 ( Cip1 ), which inhibits Cdc2
Lee et al., Cancer Res 2002
(Breast Neoplasms) :
Thus, Herceptin treatment of ErbB2 overexpressing cells can inhibit
ErbB2 mediated Cdc2-Tyr-15 phosphorylation and
p21 ( Cip1 ) up-regulation, which allows effective p34 ( Cdc2 ) activation and induction of apoptosis upon Taxol treatment
Yu et al., Mol Cell 1998
(Breast Neoplasms) :
Overexpression of
p185ErbB2 in MDA-MB-435 cells by transfection transcriptionally
upregulates p21Cip1 , which associates with p34Cdc2, inhibits Taxol mediated p34Cdc2 activation, delays cell entrance to G2/M phase, and thereby inhibits Taxol induced apoptosis