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CREB5 — DUSP1

Text-mined interactions from Literome

Zhang et al., Cell Death Differ 2008 (Second Messenger Systems) : Cyclic AMP inhibits JNK activation by CREB mediated induction of c-FLIP ( L ) and MKP-1 , thereby antagonizing UV-induced apoptosis
Cho et al., Inflamm Res 2009 : In view of the potential roles of PKA and MSK for MKP-1 induction and the ability of H89 to inhibit these kinases, this study examined the effect of H89 on MKP-1 induction by LPS and the role of cyclic-AMP response element binding protein ( CREB ) in the MKP-1 induction ... Immunoblot, gel-shift, and chromatin-immunoprecipitation assays showed the activation of CREB by LPS, and the ability of H89 to inhibit it, suggesting that H89 's inhibition of CREB may affect MKP-1 induction ... Experiments using MAPK inhibitors showed that MAPKs are involved in CREB phosphorylation and MKP-1 induction , suggesting that CREB mediated MKP-1 induction serves in part as a feedback-inhibitory loop of MAPKs ... Our results demonstrate that H89 inhibits the activation of CREB and the CREB mediated MKP-1 induction by LPS, which may result from its inhibition of PKA and MSK
Casals-Casas et al., Eur J Immunol 2009 : CREB and AP-1 activation regulates MKP-1 induction by LPS or M-CSF and their kinetics correlate with macrophage activation versus proliferation