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CTGF — HGF

Text-mined interactions from Literome

Sherriff-Tadano et al., Mod Rheumatol 2006 (Scleroderma, Diffuse...) : In addition, HGF suppressed collagen synthesis and mRNA levels of procollagenalpha1 ( I ) and connective tissue growth factor (CTGF) in SSc fibroblasts
Bogatkevich et al., Arthritis Rheum 2007 (Fibrosis...) : Pretreatment of lung fibroblasts with neutralizing anti-c-Met antibody abolished the effects of HGF on CTGF expression and collagen accumulation, suggesting that the antifibrotic activity of HGF is mediated via c-Met receptor tyrosine kinase
Kroening et al., Nephrol Dial Transplant 2009 : Regulation of connective tissue growth factor (CTGF) by hepatocyte growth factor in human tubular epithelial cells ... HGF induced a transient expression of CTGF , which was maximal after 6 h and returned to baseline after 24 h. Coincubation with TGF-beta increased CTGF protein at 6 h, whereas HGF significantly decreased CTGF induction by TGF-beta after 24 h ... The PP2 inhibitor of Src-family kinases, which regulate focal adhesion turnover, reduced HGF mediated upregulation of CTGF ... We provide evidence for a dual effect of HGF on CTGF regulation in human tubular epithelial cells : transient upregulation of CTGF in the absence of TGF-beta, which was related to alterations of cell morphology, and interference with TGF-beta mediated CTGF induction after prolonged incubation