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CRK — ROCK1
Text-mined interactions from Literome
Zeidan et al., Cardiovasc Res 2008
(Cardiomegaly) :
Leptin induced cardiomyocyte hypertrophy involves selective caveolae and
RhoA/ROCK dependent
p38 MAPK translocation to nuclei
Chaturvedi et al., Am J Physiol Cell Physiol 2011
(MAP Kinase Signaling System...) :
Furthermore, RhoA, ROCK inhibition or RhoA,
ROCK1 , ROCK2, and mDia1 reduction by siRNA also
blocked strain induced FAK-Tyr ( 925 ),
p38 , and MLC phosphorylation ... Furthermore, RhoA, ROCK inhibition or RhoA,
ROCK1 , ROCK2, and mDia1 reduction by siRNA also
blocked strain induced FAK-Tyr ( 925 ),
p38 , and MLC phosphorylation
Moey et al., J Pharmacol Exp Ther 2011
(Cardiomegaly) :
These results demonstrate a potent inhibitory effect of ginseng against leptin induced cardiac hypertrophy, an effect associated with prevention of
p115RhoGEF-RhoA/ROCK dependent
p38 MAPK
activation