Gene interactions and pathways from curated databases and text-mining

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CRK — ROCK1

Text-mined interactions from Literome

Zeidan et al., Cardiovasc Res 2008 (Cardiomegaly) : Leptin induced cardiomyocyte hypertrophy involves selective caveolae and RhoA/ROCK dependent p38 MAPK translocation to nuclei
Chaturvedi et al., Am J Physiol Cell Physiol 2011 (MAP Kinase Signaling System...) : Furthermore, RhoA, ROCK inhibition or RhoA, ROCK1 , ROCK2, and mDia1 reduction by siRNA also blocked strain induced FAK-Tyr ( 925 ), p38 , and MLC phosphorylation ... Furthermore, RhoA, ROCK inhibition or RhoA, ROCK1 , ROCK2, and mDia1 reduction by siRNA also blocked strain induced FAK-Tyr ( 925 ), p38 , and MLC phosphorylation
Moey et al., J Pharmacol Exp Ther 2011 (Cardiomegaly) : These results demonstrate a potent inhibitory effect of ginseng against leptin induced cardiac hypertrophy, an effect associated with prevention of p115RhoGEF-RhoA/ROCK dependent p38 MAPK activation