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CRK — GAB1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of CRK-GAB1 → MET (increases, CRK/GAB1 Activity)
  Evidence: Page 54 - "Crk appears to bind Gab1 in response to Met but not other receptor tyrosine kinases."
• KEGG Bacterial invasion of epithelial cells: GAB1 → CRK/CRKL (protein-protein, activation)
• KEGG Renal cell carcinoma: GAB1 → CRK/CRKL (protein-protein, activation)
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): CRK (CRK) → HGF(dimer)/MET(dimer)/GAB1 complex (MET-GAB1-HGF) (modification, collaborate)
  Lamorte et al., Oncogene 2000, Lamorte et al., J Biol Chem 2002*, Chan et al., Oncogene 2010
  Evidence: physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): CRK (CRK) → HGF(dimer)/MET(dimer)/GAB1/CRK complex (MET-GAB1-CRK-HGF) (modification, collaborate)
  Lamorte et al., Oncogene 2000, Lamorte et al., J Biol Chem 2002*, Chan et al., Oncogene 2010
  Evidence: physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): HGF(dimer)/MET(dimer)/GAB1 complex (MET-GAB1-HGF) → HGF(dimer)/MET(dimer)/GAB1/CRK complex (MET-GAB1-CRK-HGF) (modification, collaborate)
  Lamorte et al., Oncogene 2000, Lamorte et al., J Biol Chem 2002*, Chan et al., Oncogene 2010
  Evidence: physical interaction
• WikiPathways Signaling of Hepatocyte Growth Factor Receptor: GAB1 → CRK (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: GAB1 — CRK (physical association, affinity chromatography technology) Brehme et al., Proc Natl Acad Sci U S A 2009
• IRef Hprd Interaction: GAB1 — CRK (in vitro) Lamorte et al., J Biol Chem 2002*
• IRef Ophid Interaction: GAB1 — CRK (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Watanabe et al., Mol Cancer Res 2006 (Sarcoma, Synovial) : Adaptor molecule Crk is required for sustained phosphorylation of Grb2 associated binder 1 and hepatocyte growth factor induced cell motility of human synovial sarcoma cell lines
Watanabe et al., Cell Res 2009 : We have previously shown that Crk overexpression, which is detectable in various human cancers, induces tyrosine phosphorylation of Gab1 without extracellular stimuli