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ACLY — COA5

Text-mined interactions from Literome

Guay et al., J Biol Chem 2007 : However, because ACL is required for malonyl-CoA formation, inhibition of ACL expression by shRNA-ACL decreased glucose incorporation into palmitate and increased fatty acid oxidation in INS 832/13 cells
Ma et al., J Lipid Res 2009 : The ACL dependent synthesis of acetyl-CoA is thought to be an essential step for the de novo synthesis of fatty acids and cholesterol
Lee et al., Eukaryotic cell 2011 : Our previous study on ATP citrate lyase (ACL) in Gibberella zeae revealed that ACL dependent acetyl-CoA production is important for histone acetylation, especially in sexual development, but is not involved in lipid synthesis
Saha et al., Am J Physiol 1997 : Inhibition of ATP citrate lyase with hydroxycitrate markedly diminished the increases in malonyl-CoA in these muscles, indicating that citrate was the major substrate for the malonyl-CoA precursor, cytosolic acetyl-CoA