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COA1 — GCG

Text-mined interactions from Literome

Klain et al., J Nutr 1977 : Compared to the fed controls, glucagon reduced hepatic fatty acid synthesis and acetyl CoA carboxylase activity by 62 % and 65 % in fed rats, and by 51 % and 48 %, respectively, in refed rats
Berglund et al., Am J Physiol Endocrinol Metab 2010 : It blunted glucagon stimulated acetyl-CoA carboxylase phosphorylation, a downstream target of AMPK, and accentuated PPARa and FGF21 expression
Swenson et al., J Biol Chem 1985 : Mechanism of glucagon inhibition of liver acetyl-CoA carboxylase ... The observation of these effects of glucagon on acetyl-CoA carboxylase activity is absolutely dependent upon the minimization of proteolytic degradation of the enzyme after cell lysis
McGarry et al., Diabetes 1980 : At low concentrations of fatty acid the effect of glucagon was to abolish malonyl-CoA synthesis and lipogenesis and to produce a marked stimulation of fatty acid oxidation and ketogenesis