◀ Back to CDKN1B

CDKN1B — VDR

Text-mined interactions from Literome

Huang et al., Oncogene 2004 (Colonic Neoplasms...) : Vitamin D3 receptor/Sp1 complex is required for the induction of p27Kip1 expression by vitamin D3 ... In this study, we demonstrated that expression of VDR in SW620 cells, which exhibited low level of endogenous VDR, increased vitamin D3-stimulated p27Kip1 promoter activity ... Collectively, our results suggest that VDR is involved in the induction of p27Kip1 by vitamin D3 and may interact with Sp1 to modulate the expression of target genes that lack VDR response element (VDRE) in their promoters
Cheng et al., J Cell Biochem 2006 : Functional role of VDR in the activation of p27Kip1 by the VDR/Sp1 complex ... In consistent with our previous results, we found that expression of wild-type VDR in SW620 colon cancer cells, which expressed very low level of endogenous VDR, increased vitamin D3-stimulated p27Kip1 promoter activity and protein expression