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CDKN1A — HRG

Text-mined interactions from Literome

Menendez et al., Int J Oncol 2005 (Breast Neoplasms) : Pharmacological inactivation of the PI-3'K/AKT and MAPK completely prevented HRG induced accumulation of p21WAF1/CIP1 ... A structural deletion mutant of HRG ( HRG-M4 ) lacking the N-terminus sequence and the cytoplasmic-transmembrane region of HRG was generated to investigate whether secretion of HRG and transactivation of Her-2/neu actively contributed to HRG regulated p21WAF1/CIP1 expression and cellular localization
Bacus et al., Oncogene 1996 (Breast Neoplasms...) : The NDF/HRG mediated induction of p21 is dependent on wildtype p53, as it fails to occur in cells expressing dominant negative p53 ( MDD2 )
Fiddes et al., Oncogene 1998 (Breast Neoplasms) : p21 ( WAF1/CIP1/SDI1 ) gene expression was rapidly induced by HRG , but significant changes in p27 ( KIP1 ) protein levels were not detected ... Preincubation with PD98059 blocked the HRG dependent induction of cyclin D1 mRNA, p21 and c-Myc protein and pRB phosphorylation