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BAX — CDKN1A

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: BAX → CDKN1A (decreases) Javelaud et al., J Biol Chem 2002*
  Evidence: p21WAF1 deletion resulted in an increase in Bax protein expression. Quantitative analysis of the intensity of the bands revealed that the apparent Bax/Bcl2 ratio was 4-fold higher in the absence of p21WAF1.

Text-mined interactions from Literome

Frade et al., Cancer Res 2000 (Lung Neoplasms) : We herein demonstrated that RB18A, which interacted also in vivo with p53, activated Bax promoter and inhibited p21Waf1 or IGF-BP3 promoters
Giannakakou et al., Oncogene 2001 : In HCT116 cells, loss of p53 ( HCT/p53 ( -/- ) ) or p21 ( HCT/p21 ( -/- ) ) affects both Bax and Bcl-2 expression
Hayward et al., Cancer Chemother Pharmacol 2005 (Colorectal Neoplasms) : These results identify determinants of the short-term in vitro response to RM175 demonstrating a role for p53 and p21/WAF1 in the growth arrest and for p53 and Bax in the apoptotic response
Roy et al., Cell Death Differ 2005 (Prostatic Neoplasms) : TSA stabilizes the acetylation of p53 at Lys382, elevating p21 levels and inducing cell cycle arrest, but does not induce Bax translocation or apoptosis
Yang et al., Cancer Biol Ther 2005 (Esophageal Neoplasms...) : Both KLF4 and KLF5 upregulate the cdk inhibitor p21 ( waf1/cip1 ) following UV irradiation, but the pro-apoptotic protein BAX is markedly induced only by KLF5
Ghaleb et al., Oncogene 2007 : The mechanism by which KLF4 accomplished this antiapoptotic effect is by activating expression of the cell cycle arrest gene, p21 ( WAF1/CIP1 ), and by inhibiting the ability of p53 to transactivate expression of the proapoptotic gene, BAX
Alexaki et al., Pigment Cell Melanoma Res 2008 (Melanoma) : In 1205Lu cells, JNK inhibition induced cell cycle arrest through p53 dependent induction of p21 Cip1/Waf1 expression, while in WM983B cells, induction of apoptosis by JNK inhibition was accompanied by p53, Bad and Bax induction, not p21 Cip1/Waf1
Zhang et al., J Biol Chem 2008 : Overexpression of p21 suppressed MDM2, elevated p53 levels, and enhanced CD95, BAX , NOXA, and PUMA expression ; knockdown of BAX/NOXA/PUMA reduced CDK inhibitor stimulated cell killing
Braun et al., PloS one 2011 : Under these conditions, p21 prevents Puma and its downstream effector Bax from triggering the mitochondrial apoptotic pathway