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APC — CDKN1A

Pathways - manually collected, often from reviews:

• WikiPathways DNA Damage Response (only ATM dependent): Complex of GSK3B-APC → CDKN1A (activation)

Text-mined interactions from Literome

Chen et al., Cancer Res 2004 (Colonic Neoplasms) : Clusterin mediated apoptosis is regulated by adenomatous polyposis coli and is p21 dependent but p53 independent
Kuo et al., EMBO J 2006 (Cell Transformation, Viral) : These results indicate that APC activation by Tax causes inactivation of SCF ( Skp2 ) and stabilization of p21 ( CIP1/WAF1 ) and p27 ( KIP1 )
Amador et al., Mol Cell 2007 (Colonic Neoplasms...) : APC/C ( Cdc20 ) controls the ubiquitin mediated degradation of p21 in prometaphase