Pareek et al., Proc Natl Acad Sci U S A 2007
(Calcium Signaling) :
In this article we report that the Cdk5 mediated phosphorylation of TRPV1 at threonine-407 can modulate agonist induced calcium influx ... Thus, the present study indicates that Cdk5 mediated TRPV1 phosphorylation is important in the regulation of pain signaling
Utreras et al., J Biol Chem 2012
(Hyperalgesia...) :
Importantly, Cdk5 activity was reduced in the trigeminal ganglia and DRG of 14-day-old TGF-ß1 knock-out mice, resulting in reduced Cdk5 dependent phosphorylation of TRPV1 Utreras et al., Molecular pain 2013
:
In MDPC-23 cells transfected with TRPV1, Cdk5 mediated phosphorylation of TRPV1 at threonine-407 was significantly increased after TGF-ß1 treatment