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CDK10 — ETS2

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CDK10 — ETS2 (direct interaction, pull down) Kasten et al., Oncogene 2001*
• IRef Biogrid Interaction: CDK10 — ETS2 (physical association, affinity chromatography technology) Kasten et al., Oncogene 2001*
• IRef Biogrid Interaction: CDK10 — ETS2 (direct interaction, two hybrid) Kasten et al., Oncogene 2001*
• IRef Hprd Interaction: CDK10 — ETS2 (in vivo) Kasten et al., Oncogene 2001*
• IRef Hprd Interaction: CDK10 — ETS2 (two hybrid) Kasten et al., Oncogene 2001*
• IRef Hprd Interaction: CDK10 — ETS2 (in vitro) Kasten et al., Oncogene 2001*
• IRef Intact Interaction: CDK10 — ETS2 (physical association, anti tag coimmunoprecipitation) Iorns et al., Cancer Cell 2008*
• IRef Intact Interaction: CDK10 — ETS2 (physical association, anti bait coimmunoprecipitation) Iorns et al., Cancer Cell 2008*
• IRef Ophid Interaction: CDK10 — ETS2 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: CDK10 — ETS2 (aggregation, confirmational text mining) Kasten et al., Oncogene 2001*

Text-mined interactions from Literome

Kasten et al., Oncogene 2001 : The Pointed domain has been implicated in protein-protein interactions and we find that Ets2 requires an intact Pointed domain to bind Cdk10 ... We find that Cdk10 binds full length Ets2 in vitro and in vivo and inhibits Ets2 transactivation in mammalian cells
Swanton et al., Cancer Cell 2008 (Breast Neoplasms) : CDK10 loss increases the activity of the transcription factor ETS2 on the promoter of the RAF1 gene, elevating ERK/MAPK kinase pathway activity and relieving tamoxifen induced G1 arrest