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CDH1 — RHOA
Pathways - manually collected, often from reviews:
-
NCI Pathway Database E-cadherin signaling in the nascent adherens junction:
E-cadherin/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
→
RHOA/GDP complex (RHOA)
(modification, collaborate)
Anastasiadis et al., Nat Cell Biol 2000
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database E-cadherin signaling in the nascent adherens junction:
E-cadherin/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
→
p120 catenin/RhoA/GDP complex (CTNND1-RHOA)
(modification, collaborate)
Anastasiadis et al., Nat Cell Biol 2000
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database E-cadherin signaling in the nascent adherens junction:
E-cadherin/beta catenin/alpha catenin complex (CDH1-CTNNB1-CTNNA1)
→
RHOA/GDP complex (RHOA)
(modification, collaborate)
Anastasiadis et al., Nat Cell Biol 2000
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database E-cadherin signaling in the nascent adherens junction:
E-cadherin/beta catenin/alpha catenin complex (CDH1-CTNNB1-CTNNA1)
→
p120 catenin/RhoA/GDP complex (CTNND1-RHOA)
(modification, collaborate)
Anastasiadis et al., Nat Cell Biol 2000
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Stabilization and expansion of the E-cadherin adherens junction:
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
→
RHOA/GDP complex (RHOA)
(modification, activates)
Anastasiadis et al., Nat Cell Biol 2000, Yamada et al., J Cell Biol 2007, Braga et al., J Cell Biol 1997
Evidence: assay
Text-mined interactions from Literome
Patel et al., J Am Soc Nephrol 2005
(Fibrosis) :
Dominant negative
RhoA expression suppressed aPBMC-CM induced upregulation of EDA but did not
restore the expression of
E-cadherin and K19
Chang et al., Cancer Res 2006
(Colonic Neoplasms...) :
Furthermore, inhibition of
RhoA or silencing of RhoA expression with siRNA
increased the levels of
E-cadherin and alpha-catenin
Ordóñez-Morán et al., J Cell Biol 2008
(Colonic Neoplasms) :
As shown by the use of chemical inhibitors, dominant negative mutants and small interfering RNA,
RhoA-ROCK , and p38MAPK-MSK1 activation is
necessary for the induction of
CDH1/E-cadherin , CYP24, and other genes and of an adhesive phenotype by 1,25 ( OH ) ( 2 ) D ( 3 ) ... As shown by the use of chemical inhibitors, dominant negative mutants and small interfering RNA,
RhoA-ROCK , and p38MAPK-MSK1 activation is
necessary for the induction of
CDH1/E-cadherin , CYP24, and other genes and of an adhesive phenotype by 1,25 ( OH ) ( 2 ) D ( 3 )
Hutchison et al., Cell Signal 2009
:
Loss of
RhoA leads to an upregulation of Snail1 and a reduction in the transcription of
E-cadherin whereas loss of RhoC upregulates its breakdown via proteasomal degradation
Espejo et al., Am J Physiol Cell Physiol 2010
(Colonic Neoplasms) :
Adherens junction assembly is impaired following calcium switch in KM12C cells with stably knocked down PTP-PEST and is accompanied by an increase in the activity of Rac1 and a suppression of
RhoA activity in
response to
cadherin engagement
Tu et al., J Invest Dermatol 2011
:
Suppressing endogenous
Rho A expression by small interfering RNA ( siRNA ) -mediated gene silencing
blocked the Ca ( 2+ ) ( o ) -induced association of Fyn with
E-cadherin and suppressed the Ca ( 2+ ) ( o ) -induced tyrosine phosphorylation of ß-, ?-, and p120-catenin and formation of intercellular adherens junctions
Marciano et al., Development 2011
(Kidney Diseases, Cystic) :
We find that
E-cadherin knockdown, but not
RhoA inhibition , phenocopies p120ctn knockdown
Hu et al., Tumour Biol 2012
(Liver Neoplasms...) :
miR-143 expression significantly decreased mRNA and protein levels of GEF1, GEF2, and K-RAS genes ; lowered the constitutive activities of
RhoA , Rac1, and Cdc42 GTPases ; decreased the protein levels of MMP-2 and MMP-9 ; but significantly
increased the protein level of
E-cadherin
Xue et al., Eur J Oral Sci 2013
:
Hypoplastic enamel in transgenic mice correlates with reduced expression of the enamel protein, amelogenin, and
E-cadherin and cell proliferation are
regulated by
RhoA in other tissues