◀ Back to CDH1
CDH1 — PSEN1
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
CDH1
→
PSEN1
(reaction)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
CDH1
—
PSEN1
(physical association, affinity chromatography technology)
Georgakopoulos et al., Mol Cell 1999*
-
IRef Biogrid Interaction:
CDH1
—
PSEN1
(physical association, affinity chromatography technology)
Serban et al., J Biol Chem 2005*
-
IRef Hprd Interaction:
PSEN1
—
CDH1
(in vivo)
Georgakopoulos et al., Mol Cell 1999*, Baki et al., Proc Natl Acad Sci U S A 2001*, Marambaud et al., EMBO J 2002
-
IRef Hprd Interaction:
PSEN1
—
CDH1
(in vitro)
Georgakopoulos et al., Mol Cell 1999*, Baki et al., Proc Natl Acad Sci U S A 2001*, Marambaud et al., EMBO J 2002
-
IRef Innatedb Interaction:
Complex of CDH1-PSEN1-CTNNB1
(unknown, -)
Serban et al., J Biol Chem 2005*
-
IRef Innatedb Interaction:
PSEN1
—
CDH1
(unknown, -)
Serban et al., J Biol Chem 2005*
-
IRef Intact Interaction:
PSEN1
—
CDH1
(physical association, coimmunoprecipitation)
Marambaud et al., EMBO J 2002
-
IRef Ophid Interaction:
PSEN1
—
CDH1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Baki et al., Proc Natl Acad Sci U S A 2001
:
Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and
regulates stability and function of the
cadherin/catenin adhesion complex ... Using wild-type and PS1 knockout cells, we found that increasing
PS1 levels
suppresses p120/E-cadherin binding, and increasing p120 levels suppresses PS1/E-cadherin binding ... Furthermore,
PS1 stimulates
E-cadherin binding to beta- and gamma-catenin, promotes cytoskeletal association of the cadherin/catenin complexes, and increases Ca ( 2+ ) -dependent cell-cell aggregation
Marambaud et al., EMBO J 2002
:
Here we show that
presenilin-1 (PS1) , a protein involved in Alzheimer 's disease,
controls a gamma-secretase-like cleavage of
E-cadherin
Uemura et al., J Biol Chem 2007
(Alzheimer Disease) :
Glycogen synthase kinase 3beta mediated phosphorylation of
Presenilin 1 reduces its binding to
N-cadherin , thereby down regulating its cell-surface expression