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CDC42 — TNK2

Pathways - manually collected, often from reviews:

• NCI Pathway Database CDC42 signaling events: CDC42/GTP complex (CDC42) → CDC42/GTP/ACK1 complex (CDC42-TNK2) (modification, collaborate)
  Mott et al., Nature 1999*, Modzelewska et al., J Biol Chem 2006*, Manser et al., Nature 1993*
  Evidence: assay, physical interaction
• NCI Pathway Database CDC42 signaling events: CDC42/GTP complex (CDC42) → ACK1 (TNK2) (modification, collaborate) Mott et al., Nature 1999*, Modzelewska et al., J Biol Chem 2006*, Manser et al., Nature 1993*
  Evidence: assay, physical interaction
• NCI Pathway Database CDC42 signaling events: CDC42/GTP/ACK1 complex (CDC42-TNK2) → ACK1 (TNK2) (modification, collaborate) Mott et al., Nature 1999*, Modzelewska et al., J Biol Chem 2006*, Manser et al., Nature 1993*
  Evidence: assay, physical interaction
• NCI Pathway Database CDC42 signaling events: CDC42/GTP/ACK1 complex (CDC42-TNK2) → p130 Cas (BCAR1) (modification, activates) Modzelewska et al., J Biol Chem 2006*
  Evidence: mutant phenotype
• WikiPathways G13 Signaling Pathway: CDC42 → TNK2 (activation)
• WikiPathways Oxidative Damage: TNK2 → CDC42 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: TNK2 — CDC42 Mott et al., Nature 1999*
• IRef Bind_translation Interaction: TNK2 — CDC42 (x-ray crystallography) Mott et al., Nature 1999*
• IRef Biogrid Interaction: CDC42 — TNK2 (direct interaction, pull down) Mott et al., Nature 1999*
• IRef Biogrid Interaction: CDC42 — TNK2 (direct interaction, pull down) Owen et al., Biochemistry 2000*
• IRef Biogrid Interaction: CDC42 — TNK2 (direct interaction, two hybrid) Bandyopadhyay et al., Nat Methods 2010
• IRef Biogrid Interaction: CDC42 — TNK2 (physical association, affinity chromatography technology) Kato-Stankiewicz et al., Biochem Biophys Res Commun 2001*
• IRef Biogrid Interaction: CDC42 — TNK2 (physical association, affinity chromatography technology) Lin et al., Mol Cell Biol 2010*
• IRef Biogrid Interaction: CDC42 — TNK2 (direct interaction, two hybrid) Govind et al., J Cell Biol 2001*
• IRef Biogrid Interaction: CDC42 — TNK2 (association, x-ray crystallography) Mott et al., Nature 1999*
• IRef Biogrid Interaction: CDC42 — TNK2 (direct interaction, pull down) Gu et al., J Biol Chem 2004*
• IRef Hprd Interaction: TNK2 — CDC42 (in vitro) Morreale et al., Nat Struct Biol 2000*, Kato-Stankiewicz et al., Biochem Biophys Res Commun 2001*
• IRef Hprd Interaction: TNK2 — CDC42 (in vivo) Morreale et al., Nat Struct Biol 2000*, Kato-Stankiewicz et al., Biochem Biophys Res Commun 2001*
• IRef Intact Interaction: TNK2 — CDC42 (direct interaction, nuclear magnetic resonance) Mott et al., Nature 1999*
• IRef Intact Interaction: TNK2 — CDC42 (physical association, two hybrid) Govind et al., J Cell Biol 2001*
• IRef Intact Interaction: TNK2 — CDC42 (physical association, two hybrid pooling approach) Bandyopadhyay et al., Nat Methods 2010
• IRef Ophid Interaction: TNK2 — CDC42 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: TNK2 — CDC42 (aggregation, confirmational text mining) Kato-Stankiewicz et al., Biochem Biophys Res Commun 2001*

Text-mined interactions from Literome

Kato-Stankiewicz et al., Biochem Biophys Res Commun 2001 : Specific inhibition of the interaction of ACK1 with Cdc42 or Grb2 by the use of these constructs diminished tyrosine phosphorylation of both ACK1 and Dbl in response to EGF
Liu et al., J Biol Chem 2009 (Breast Neoplasms) : Therefore, a cascade of activation of Cdc42 and Rac1 by Dbs through the Cdc42 effector Ack1 and the Crk.p130 ( Cas ) complex is established