Gene interactions and pathways from curated databases and text-mining

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CD40LG — PRL

Text-mined interactions from Literome

Chavez-Rueda et al., Clin Exp Rheumatol 2005 (Lupus Erythematosus, Systemic) : Prolactin effect on CD69 and CD154 expression by CD4+ cells from systemic lupus erythematosus patients
Peeva et al., J Immunol 2006 (Genetic Predisposition to Disease...) : The increase in costimulation due to prolactin mediated up-regulation of both CD40 on B cells and CD40L on T cells would appear to play a central role in lupus induction in this model
Wang et al., Nan Fang Yi Ke Da Xue Xue Bao 2007 (Lupus Erythematosus, Systemic) : [ Effect of prolactin on CD40/CD154 expression on peripheral blood mononuclear cells in patients with systemic lupus erythematosus ] ... CD154 significantly increased on the PBMCs in SLE patients with high serum prolectin level in comparison with that in patients with normal prolactin level or the normal controls ( P < 0.05 ). When the PBMCs were incubated with recombinant human prolactin, CD154 expression was significantly increased in SLE patients with normal serum prolactin level ( P < 0.05 ), but not in the normal control group ( P > 0.05 )