◀ Back to CCNC
CCNC — CDK8
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
CCNC
→
CDK8
(direct_complex)
Rachez et al., Nature 1999, Näär et al., Annu Rev Biochem 2001, Bourbon et al., Mol Cell 2004, Malik et al., Trends Biochem Sci 2005, Maston et al., Annu Rev Genomics Hum Genet 2006, Kelleher et al., Cell 1990, Rachez et al., Genes Dev 1998, Yuan et al., Proc Natl Acad Sci U S A 1998
-
Reactome Reaction:
CCNC
→
CDK8
(reaction)
Rachez et al., Nature 1999, Näär et al., Annu Rev Biochem 2001, Bourbon et al., Mol Cell 2004, Fryer et al., Mol Cell 2004, Malik et al., Trends Biochem Sci 2005, Maston et al., Annu Rev Genomics Hum Genet 2006, Kelleher et al., Cell 1990, Rachez et al., Genes Dev 1998, Yuan et al., Proc Natl Acad Sci U S A 1998
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
CCNC
—
CDK8
(physical association, affinity chromatography technology)
Boyer et al., Nature 1999*
-
IRef Biogrid Interaction:
CCNC
—
CDK8
(physical association, affinity chromatography technology)
Malik et al., Mol Cell 2000
-
IRef Biogrid Interaction:
CCNC
—
CDK8
(direct interaction, pull down)
-
IRef Biogrid Interaction:
CCNC
—
CDK8
(physical association, affinity chromatography technology)
Zhang et al., Cell 1997
-
IRef Biogrid Interaction:
CCNC
—
CDK8
(colocalization, biochemical)
Cho et al., Mol Cell Biol 1998
-
IRef Biogrid Interaction:
CCNC
—
CDK8
(physical association, affinity chromatography technology)
Wang et al., Mol Cell Biol 2001*
-
IRef Biogrid Interaction:
CCNC
—
CDK8
(physical association, affinity chromatography technology)
Kang et al., Proc Natl Acad Sci U S A 2002
-
IRef Biogrid Interaction:
CCNC
—
CDK8
(direct interaction, pull down)
Tassan et al., Proc Natl Acad Sci U S A 1995*
-
IRef Biogrid Interaction:
CCNC
—
CDK8
(physical association, affinity chromatography technology)
Tassan et al., Proc Natl Acad Sci U S A 1995*
-
IRef Biogrid Interaction:
CCNC
—
CDK8
(association, biochemical)
Gu et al., Mol Cell 1999
-
MIPS CORUM SMCC complex:
SMCC complex complex (CCNC-CDK8-MED1-MED14-MED21-MED24-MED31-MED6)
Gu et al., Mol Cell 1999
-
MIPS CORUM NAT complex:
NAT complex complex (CCNC-CDK8-MED10-MED14-MED21-MED23-MED6)
Sun et al., Mol Cell 1998
-
MIPS CORUM Mediator complex:
Mediator complex complex (CCNC-CDK19-CDK8-MED1-MED10-MED11-MED12-MED13-MED13L-MED14-MED15-MED16-MED17-MED18-MED20-MED21-MED22-MED23-MED24-MED25-MED26-MED27-MED28-MED29-MED30-MED31-MED4-MED6-MED7-MED8-MED9-MED19)
Sato et al., Mol Cell 2004
-
MIPS CORUM CCNC-CDK8-MED1-MED6-MED7 xcomplex:
CCNC-CDK8-MED1-MED6-MED7 xcomplex complex (CCNC-CDK8-MED1-MED6-MED7)
Pavri et al., Mol Cell 2005
-
MIPS CORUM ARC-L complex:
ARC-L complex complex (CCNC-CDK8-MED1-MED12-MED13-MED14-MED15-MED17-MED21-MED23-MED24-MED25-MED6-MED7)
Taatjes et al., Science 2002
-
MIPS CORUM ARC complex:
ARC complex complex (CCNC-CDK8-MED1-MED12-MED13-MED14-MED15-MED17-MED21-MED23-MED24-MED25-MED26-MED6-MED7)
Taatjes et al., Science 2002
-
MIPS CORUM SMCC complex:
SMCC complex complex (CCNC-CDK8-MED1-MED10-MED12-MED13-MED14-MED16-MED17-MED20-MED21-MED24-MED27-MED31-MED6-MED7-THRAP3)
Malik et al., Mol Cell 2000
-
MIPS CORUM RNA polymerase II complex (RPB1, RAP74, CDK8, CYCC, SRB7, BAF190, BAF47), chromatin structure modifying:
RNA polymerase II complex (RPB1, RAP74, CDK8, CYCC, SRB7, BAF190, BAF47), chromatin structure modifying complex (CCNC-CDK8-GTF2F1-MED21-POLR2A-SMARCB1-SMARCA2-SMARCA4)
Cho et al., Mol Cell Biol 1998
-
MIPS CORUM RNA polymerase II complex (CBP, PCAF, RPB1, BAF47, CYCC, CDK8), chromatin structure modifying:
RNA polymerase II complex (CBP, PCAF, RPB1, BAF47, CYCC, CDK8), chromatin structure modifying complex (CCNC-CDK8-CREBBP-KAT2B-POLR2A-SMARCB1)
Cho et al., Mol Cell Biol 1998
-
MIPS CORUM RNA polymerase II complex, chromatin structure modifying:
RNA polymerase II complex, chromatin structure modifying complex (CCNC-CDK8-DRAP1-GTF2B-GTF2E1-GTF2F1-GTF2H1-MED21-PCSK4-POLR2A-SMARCB1-SMARCC1-SMARCC2-TBP-SMARCA2-SMARCA4-SMARCD1-SMARCD2-SMARCD3)
Cho et al., Mol Cell Biol 1998
-
MIPS CORUM RNA polymerase II complex, chromatin structure modifying:
RNA polymerase II complex, chromatin structure modifying complex (ACTL6A-CCNC-CDK8-MED21-SMARCB1-SMARCC1-SMARCC2-SMARCE1-SMARCD1-SMARCD2-SMARCD3)
Cho et al., Mol Cell Biol 1998
-
MIPS CORUM RNA polymerase II complex, chromatin structure modifying:
RNA polymerase II complex, chromatin structure modifying complex (CCNC-CDK8-CREBBP-ERCC3-GTF2B-GTF2F1-GTF2H3-MED21-KAT2B-POLR2A-SMARCA2-SMARCA4-SMARCB1)
Cho et al., Mol Cell Biol 1998
-
MIPS CORUM RNA polymerase II complex, incomplete (CDK8 complex), chromatin structure modifying:
RNA polymerase II complex, incomplete (CDK8 complex), chromatin structure modifying complex (CCNC-CCNH-CDK8-GTF2F1-MED21-SMARCB1-SMARCC1-SMARCC2)
Cho et al., Mol Cell Biol 1998
-
MIPS CORUM SMCC complex:
SMCC complex complex (CCNC-CDK8-MED1-MED12-MED13-MED14-MED16-MED17-MED21-MED24-MED27-MED4-MED6-THRAP3)
Ito et al., Mol Cell 1999
-
MIPS CORUM hMediator complex (MED23, CDK8, CCNC, MED7):
hMediator complex (MED23, CDK8, CCNC, MED7) complex (CCNC-CDK8-MED23-MED7)
Boyer et al., Nature 1999*
-
MIPS CORUM hMediator complex (MED23, CDK8, CCNC):
hMediator complex (MED23, CDK8, CCNC) complex (CCNC-CDK8-MED23)
Wang et al., Mol Cell Biol 2001*
-
MIPS CORUM CDK8-CyclinC-Mediator complex:
CDK8-CyclinC-Mediator complex complex (CCNC-CDK8)
Wang et al., Mol Cell Biol 2001*
-
MIPS CORUM Mediator complex 1:
Mediator complex 1 complex (CCNC-CDK8-MED14-MED23-MED6)
Wang et al., Mol Cell Biol 2001*
-
IRef Corum Interaction:
Complex of CCNC-POLR2A-CDK8-SMARCB1-CREBBP-KAT2B
(association, ion exchange chromatography)
Cho et al., Mol Cell Biol 1998
-
IRef Corum Interaction:
Complex of CCNC-CCNC-CDK8-CDK8-MED23-MED23
(association, molecular sieving)
Wang et al., Mol Cell Biol 2001*
-
IRef Corum Interaction:
Complex of MED14-MED6-CCNC-CDK8-MED21-MED10-MED23
(association, coimmunoprecipitation)
Sun et al., Mol Cell 1998
-
IRef Corum Interaction:
Complex of 15 proteins
(association, affinity chromatography technology)
Ito et al., Mol Cell 1999
-
IRef Corum Interaction:
Complex of 31 proteins
(association, affinity chromatography technology)
Taatjes et al., Science 2002
-
IRef Corum Interaction:
Complex of 65 proteins
(association, anti tag coimmunoprecipitation)
Sato et al., Mol Cell 2004
-
IRef Corum Interaction:
Complex of 11 proteins
(association, anti bait coimmunoprecipitation)
Wang et al., Mol Cell Biol 2001*
-
IRef Corum Interaction:
Complex of 13 proteins
(association, ion exchange chromatography)
Boyer et al., Nature 1999*
-
IRef Corum Interaction:
Complex of 18 proteins
(association, anti tag coimmunoprecipitation)
Malik et al., Mol Cell 2000
-
IRef Corum Interaction:
Complex of 27 proteins
(association, far western blotting)
Cho et al., Mol Cell Biol 1998
-
IRef Corum Interaction:
Complex of MED14-MED24-MED6-CCNC-CDK8-MED21-MED1-MED31
(association, anti tag coimmunoprecipitation)
Gu et al., Mol Cell 1999
-
IRef Corum Interaction:
Complex of CDK8-CCNC-MED6-MED7-MED1
(association, coimmunoprecipitation)
Pavri et al., Mol Cell 2005
-
IRef Corum Interaction:
CCNC
—
CDK8
(association, molecular sieving)
Wang et al., Mol Cell Biol 2001*
-
IRef Corum Interaction:
CCNC
—
CDK8
(association, anti bait coimmunoprecipitation)
Wang et al., Mol Cell Biol 2001*
-
IRef Corum Interaction:
Complex of SMARCA4-SMARCA2-POLR2A-CCNC-CDK8-GTF2F1-SMARCB1-MED21
(association, far western blotting)
Cho et al., Mol Cell Biol 1998
-
IRef Corum Interaction:
Complex of 20 proteins
(association, affinity chromatography technology)
Cho et al., Mol Cell Biol 1998
-
IRef Corum Interaction:
Complex of 29 proteins
(association, cosedimentation through density gradient)
Taatjes et al., Science 2002
-
IRef Corum Interaction:
Complex of 12 proteins
(association, far western blotting)
Cho et al., Mol Cell Biol 1998
-
IRef Corum Interaction:
Complex of CCNC-GTF2F1-CDK8-CCNH-SMARCB1-MED21-SMARCC2-SMARCC1
(association, far western blotting)
Cho et al., Mol Cell Biol 1998
-
IRef Dip Interaction:
Complex of MED13-CCNC-CDK9-MED15-CDK8-CCNT1-MED12-BRD4
(anti bait coimmunoprecipitation)
Donner et al., Nature structural & molecular biology 2010
-
IRef Dip Interaction:
CCNC
—
CDK8
(physical association, anti bait coimmunoprecipitation)
Donner et al., Nature structural & molecular biology 2010
-
IRef Hprd Interaction:
Complex of 17 proteins
(in vivo)
Sun et al., Mol Cell 1998
-
IRef Hprd Interaction:
Complex of 26 proteins
(in vivo)
Sun et al., Mol Cell 1998
-
IRef Hprd Interaction:
Complex of 43 proteins
(in vivo)
Gu et al., Mol Cell 1999
-
IRef Hprd Interaction:
Complex of 273 proteins
(in vivo)
Sato et al., Mol Cell 2004
-
IRef Hprd Interaction:
Complex of 307 proteins
(in vivo)
Sato et al., Mol Cell 2004
-
IRef Hprd Interaction:
Complex of 82 proteins
(in vivo)
Cho et al., Mol Cell Biol 1998
-
IRef Hprd Interaction:
CCNC
—
CDK8
(in vivo)
Wang et al., Mol Cell Biol 2001*, Tassan et al., Proc Natl Acad Sci U S A 1995*
-
IRef Hprd Interaction:
CCNC
—
CDK8
(in vitro)
Wang et al., Mol Cell Biol 2001*, Tassan et al., Proc Natl Acad Sci U S A 1995*
-
IRef Intact Interaction:
Complex of 43 proteins
(association, anti tag coimmunoprecipitation)
Sato et al., Mol Cell 2004
-
IRef Intact Interaction:
Complex of 115 proteins
(association, anti tag coimmunoprecipitation)
Sato et al., Mol Cell 2004
-
IRef Intact Interaction:
Complex of 82 proteins
(association, anti tag coimmunoprecipitation)
Sato et al., Mol Cell 2004
-
IRef Intact Interaction:
Complex of 64 proteins
(association, anti tag coimmunoprecipitation)
Sato et al., Mol Cell 2004
-
IRef Intact Interaction:
Complex of 31 proteins
(association, tandem affinity purification)
Varjosalo et al., Cell reports 2013
-
IRef Intact Interaction:
Complex of CDK8-SMAD1-CCNC
(phosphorylation reaction, protein kinase assay)
Alarcón et al., Cell 2009
-
IRef Intact Interaction:
CCNC
—
CDK8
(direct interaction, inferred by curator)
Hermjakob et al., Nucleic Acids Res 2004
-
IRef Intact Interaction:
CCNC
—
CDK8
(direct interaction, fluorescent resonance energy transfer)
Schneider et al., J Mol Biol 2011*
-
IRef Intact Interaction:
CCNC
—
CDK8
(direct interaction, anti bait coimmunoprecipitation)
Tassan et al., Proc Natl Acad Sci U S A 1995*
-
IRef Intact Interaction:
CCNC
—
CDK8
(direct interaction, pull down)
Tassan et al., Proc Natl Acad Sci U S A 1995*
-
IRef Ophid Interaction:
CCNC
—
CDK8
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Lee et al., Mol Cell Biol 1999
:
The
Mediator complex of Saccharomyces cerevisiae is
required for both general and regulated transcription of
RNA polymerase II (PolII) and is composed of two stable subcomplexes ( Srb4 and Rgr1 subcomplexes )
Lo et al., Anticancer Res 1999
:
CA,
CGA and FA could
suppress the bacterial
NAT activities dose-dependently both in the intact cell and cytosolic fraction analysis ... These results strongly demonstrated that CA,
CGA and FA
inhibited NAT activities in human gastrointestinal bacteria
Bryan-Lluka et al., Naunyn Schmiedebergs Arch Pharmacol 1999
:
Haloperidol, its five metabolites and
MPP+ and MPTP all
inhibited NAT , DAT and SERT
Ekhterae et al., Circ Res 1999
:
Loss of endogenous ARC in the cytosol of H9c2 cells was associated with translocation of
ARC from the cytosol to intracellular membranes, release of cytochrome c from the mitochondria,
activation of
caspase-3 , poly ( ADP-ribose ) polymerase ( PARP ) cleavage, and DNA fragmentation
Spåhr et al., J Biol Chem 2000
:
This stimulation was species-specific, because S. pombe
Mediator could not
stimulate TFIIH purified from S. cerevisiae
Alonso-Gómez et al., Life Sci 2000
:
A D2-like receptor is directly
involved in the regulation of
NAT activity and melatonin release in R. perezi retina
Guzowski et al., J Neurosci 2001
:
Arc RNA expression differed from that of zif268 and c-fos in two regards : ( 1 ) hippocampal
Arc RNA levels were correlated with learning of the hippocampal dependent spatial, but not hippocampal independent cued response, water task, and ( 2 )
Arc RNA levels in the hippocampus and entorhinal cortex
increased after spatial reversal learning relative to an asymptotic performance group
Waltereit et al., J Neurosci 2001
:
Arg3.1/Arc mRNA
induction by
Ca2+ and cAMP requires protein kinase A and mitogen activated protein kinase/extracellular regulated kinase activation ...
Arg3.1/Arc mRNA induction by Ca2+ and cAMP
requires protein kinase A and
mitogen activated protein kinase/extracellular regulated kinase activation
Soros et al., J Virol 2001
:
It has previously been reported that
Sam68 synergistically
stimulates Rev activity ( T. Reddy et al.,
Nat
Mittler et al., EMBO Rep 2001
:
Novel critical
role of a human
Mediator complex for basal
RNA polymerase II transcription
Elmquist et al., Physiol Behav 2001
(Body Weight) :
We found that
leptin activates neurons in the retrochiasmatic area ( RCA ) and lateral
arcuate nucleus (Arc) that innervate the sympathetic preganglionic neurons in the thoracic spinal cord and also contain cocaine- and amphetamine regulated transcript ( CART )
Kremerskothen et al., Neurosci Lett 2002
(Neuroblastoma) :
Insulin induced expression of the activity regulated cytoskeleton associated gene (
ARC ) in human neuroblastoma cells
requires p21(ras) , mitogen activated protein kinase/extracellular regulated kinase and src tyrosine kinases but is protein kinase C-independent ...
Insulin induced expression of the activity regulated cytoskeleton associated gene (
ARC ) in human neuroblastoma cells requires p21(ras), mitogen activated protein kinase/extracellular regulated kinase and src tyrosine kinases but is protein kinase C-independent
Ying et al., J Neurosci 2002
:
Brain derived neurotrophic factor induces long-term potentiation in intact adult hippocampus :
requirement for ERK activation coupled to CREB and upregulation of
Arc synthesis
Wang et al., J Biol Chem 2002
:
Mediator role of platelet derived growth factor and
ERK
Wang et al., J Virol 2002
(Cell Transformation, Viral) :
Much of the large E1A bound to Mediator in 293 cells is in a stable complex that includes RNA polymerase II, leading us to suggest that the interaction of E1A-CR3 with
Mediator stabilizes the interaction of
Mediator with the polymerase
Proulx et al., Endocrinology 2002
(Weight Gain) :
In the
arcuate nucleus (ARC) , acute
leptin increased SOCS-3 and POMC mRNA levels, but decreased NPY mRNA levels in the rostral part of ARC
Leineweber et al., Circ Res 2002
(Disease Models, Animal...) :
Twenty-one to twenty-eight days after MCT ( group B ), however, not only RV weight ( 316+/-4 versus 148+/-2 mg ) and RV/LV weight ratio ( 0.61+/-0.01 versus 0.3+/-0.01 ) were markedly increased but also plasma noradrenaline ( 645+/-63 versus 278+/-18 pg/mL ) ; now, RV beta-AR density ( 13.4+/-1.3 versus 26.5+/-1.1 fmol/mg protein ), RV NAT density ( 50.9+/-11.3 versus 79.6+/-2.9 fmol/mg protein ), and RV
NAT activity ( 65.4+/-7.4 versus 111.8+/-15.9 pmol [ 3H ] -NA/mg tissue slices/15 min ) were significantly decreased and RV-membrane
GRK activity ( 100+/-15 versus 67+/-6 [ 32P ] -rhodopsin in cpm ) significantly
increased
Acevedo et al., Mol Cell Biol 2003
:
We have used a biochemical approach, including an in vitro chromatin assembly and transcription system, to examine the functional
role for
Mediator in the transcriptional activity of
estrogen receptor alpha (ERalpha) with chromatin templates, as well as functional interplay between Mediator and p300/CBP during ERalpha dependent transcription ... Using three different approaches to functionally inactivate Mediator ( immunoneutralization, immunodepletion, and inhibitory polypeptides ), we find that
Mediator is
required for maximal transcriptional activation by ligand activated
ERalpha
Kumpawat et al., Mutat Res 2003
(Chromosome Aberrations) :
The present data indicate that the generation of ROS by ARC could partially contribute to the induction of chromosomal aberrations (CAs), since the frequency of
ARC induced
CAs was reduced either by post-treatment with superoxide dismutase ( SOD ) or in anoxic conditions
Zakharova et al., J Biol Chem 2003
:
Furthermore, in a system with purified proteins and naked DNA,
STAT1alpha- and STAT1beta dependent transcription is
stimulated by the
TRAP/Mediator co-activator complex ... Furthermore, in a system with purified proteins and naked DNA,
STAT1alpha- and STAT1beta dependent transcription is
stimulated by the
TRAP/Mediator co-activator complex
Zawilska et al., Acta Neurobiol Exp (Wars) 1992
:
It is suggested that
Ca2+ may
regulate NAT activity indirectly, by affecting the intracellular cyclic AMP content, which is, in turn, critical in the regulation of melatonin biosynthesis
Gupta et al., Journal of neural transmission. General section 1992
:
Norepinephrine ( NE ), Delta sleep inducing peptide ( DSIP ),
vasoactive intestinal polypeptide (VIP) , adenosine and N-acetyl-asp-glu ( NAAG ) significantly
increased NAT activity in rat pineal ... Norepinephrine ( NE ), Delta sleep inducing peptide ( DSIP ), vasoactive intestinal polypeptide (VIP), adenosine and
N-acetyl-asp-glu ( NAAG ) significantly
increased NAT activity in rat pineal ... DSIP and
VIP also
increase the stimulatory effect of NE on
NAT activity
Malabu et al., Peptides 1992
(Body Weight) :
We tested the hypothesis that low plasma
insulin levels
stimulate ARC levels of NPY in fasted rats
Marshall et al., Vox Sang 2004
(HIV Infections...) :
SS + minipool
NAT -
p24 compared with SS alone
resulted in an incremental cost-effectiveness ratio of 1.5 million per QALY gained ( range in sensitivity analysis 1.0-2.1 million per QALY gained ) in this US analysis
Fujimoto et al., J Neurosci Res 2004
(Seizures) :
Arc interacts with microtubules/microtubule associated protein 2 and
attenuates microtubule associated protein 2 immunoreactivity in the dendrites ... We found that the overexpression of
Arc as well as
Arc induction by seizure in vivo decreased microtubule associated protein 2 (MAP2) staining in the dendrites by immunocytochemistry, although MAP2 content was not changed on Western blot
Guidi et al., J Biol Chem 2004
:
Mediator , a global transcriptional co-activator, dramatically
enhances the phosphorylation of the
CTD of RNA pol II by holo-TFIIH in vitro ... Using purified proteins we have determined that the subunits of TFIIK are sufficient for Mediator to enhance Kin28 CTD kinase activity and that
Mediator enhances phosphorylation of a
glutathione S-transferase-CTD fusion protein, despite the absence of multiple Mediator and/or TFIIH interactions with polymerase ... Using purified proteins we have determined that the subunits of TFIIK are sufficient for Mediator to enhance Kin28 CTD kinase activity and that
Mediator enhances phosphorylation of a glutathione
S-transferase-CTD fusion protein, despite the absence of multiple Mediator and/or TFIIH interactions with polymerase
Sato et al., Mol Cell 2004
:
The
Mediator is a multiprotein transcriptional coactivator that is expressed ubiquitously in eukaryotes from yeast to mammals and is
required for induction of
RNA polymerase II (pol II) transcription by DNA binding transcription factors ... The
Mediator is a multiprotein transcriptional coactivator that is expressed ubiquitously in eukaryotes from yeast to mammals and is
required for induction of RNA
polymerase II (pol II) transcription by DNA binding transcription factors
Caesar et al., J Biol Chem 2004
:
The
involvement of
Nat3p and Tfs1p in
PKA signaling was supported by caffeine growth inhibition studies
Huber et al., Environ Mol Mutagen 2004
:
K/C decreased hepatic
NAT dependent
PhIP activation by up to 80 % in a dose dependent manner
Liu et al., J Biol Chem 2004
:
However, the effect of Aurora-A on
p53 DNA binding and transactivation activity was not
affected by phosphorylation of Ser-315, a recently identified Aurora-A phosphorylation site of p53 ( Katayama, H., Sasai, K., Kawai, H., Yuan, Z. M., Bondaruk, J., Suzuki, F., Fujii, S., Arlinghaus, R. B., Czerniak, B. A., and Sen, S. ( 2004 )
Nat
Wang et al., Genetics 2004
:
The rgr1 and sin4 constitutive phenotype does not require either the MAL-activator or maltose permease, indicating that
Mediator represses
MAL basal expression ... The
role of the
Mediator in
MAL gene regulation is discussed
Hassan et al., Proc Natl Acad Sci U S A 1992
:
Regulatory
roles of Fnr, Fur, and
Arc in expression of manganese containing
superoxide dismutase in Escherichia coli
Santanavanich et al., J Pineal Res 2005
:
Taken together with our previous data, the results indicate that activation of D1-dopamine receptor in bovine pinealocyte stimulates
NAT activity and
enhances melatonin level whereas activation of
D2-dopamine receptor leads to an inhibitory effect and these stimulatory and inhibitory effects act, in part, via a cAMP dependent transcription mechanism
Pavri et al., Mol Cell 2005
:
Importantly,
Mediator was inactive ( Cdk8+ ) under basal conditions but was
activated (
Cdk8- ) upon induction
Malik et al., Trends Biochem Sci 2005
:
Dynamic
regulation of
pol II transcription by the mammalian
Mediator complex
Smith et al., Endocrinology 2005
(Body Weight) :
In the
arcuate nucleus (Arc) ,
KiSS-1 expression
increased after ovariectomy and decreased with E2 treatment
Govind et al., Mol Cell Biol 2005
:
We confirm the
roles of
Mediator and SAGA in
TATA binding protein (TBP) recruitment and demonstrate that all four coactivators under study enhance Pol II recruitment or promoter clearance following TBP binding
Gaertner et al., J Control Release 2005
:
The mechanism by which
ARC-encapsulation increased
IFN-gamma activity in vivo remains uncertain
Bramham et al., Prog Neurobiol 2005
:
Recent experiments suggest that
BDNF activates synaptic consolidation through transcription and rapid dendritic trafficking of mRNA encoded by the immediate early gene,
Arc
Takagi et al., J Biol Chem 2006
:
Taken together, these findings lead to the suggestion that
Mediator is
required for basal
RNA polymerase II transcription in vivo
Lee et al., In Vivo 2005
(Adenocarcinoma...) :
The main objective of this study was to document the
effects of
5-MOP on the modulation of
NAT activities in the stomach and colon of rats and human stomach and colon tumor cell lines ...
5-MOP more efficiently
inhibited NAT activity in human stomach and colon tumor cell lines than in the stomach and colon of rats
Huber et al., Methods Enzymol 2005
(Neoplasms) :
Other coffee components such as polyphenols and K/C-free coffee are also capable of increasing
GST and partially of
inhibiting NAT , although to a somewhat lesser extent
Wang et al., Neurosci Lett 2006
:
Consistent with the literature,
Arc , an indicator of synaptic plasticity, was
induced by
BDNF ( 25 ng/ml ) in both dose- and time dependent manners
Radhakrishnan et al., Cancer Res 2006
(Neoplasms...) :
Specifically,
ARC inhibits the phosphorylation of
RNA polymerase II by positive transcription elongation factor-b, leading to a block in transcriptional elongation ... Although
ARC promoted the accumulation of
p53 , ARC induced apoptosis in tumor cells was p53 independent, suggesting that it may be useful for the treatment of tumors with functionally inactive p53
Kim et al., J Biol Chem 2006
:
The beta-catenin transactivation domain bound directly to isolated MED12 and intact Mediator both in vitro and in vivo, and
Mediator was recruited to Wnt-responsive genes in a
beta-catenin dependent manner
Withyachumnarnkul et al., Int J Biochem 1991
:
10. The results indicate that the
IFN-gamma induced
NAT suppression requires the integrity of the sympathetic nerve terminals and the IFN-gamma induced enhancement of melatonin production is accomplished through its direct action on pinealocytes
Steinberg et al., Endocrinology 2006
(Obesity) :
Intracerebroventricular
CNTF ( Ax15 ) reduced food intake,
increased arcuate nucleus (ARC) signal transducer and activator of transcription 3 phosphorylation, and reduced AMPK signaling but not in the paraventricular nucleus ( PVN ), posterior hypothalamus, or cortex ... Both leptin and
CNTF reduced AMPK activity and acetyl-coenzyme A carboxylase phosphorylation in the
ARC and PVN of control fed mice ... Both
leptin and CNTF
reduced AMPK activity and acetyl-coenzyme A carboxylase phosphorylation in the
ARC and PVN of control fed mice
Black et al., Mol Cell 2006
:
Using purified proteins, we found that the
Mediator regulates this assembly process by binding to p300 and
TFIID
Withyachumnarnkul et al., J Pineal Res 1990
:
IFN-gamma had no effect on either
NAT or HIOMT activities in the pineal glands
Zhou et al., Mol Cell Biol 2006
:
We propose that activated Gli3 physically targets the MED12 interface within Mediator in order to functionally reverse
Mediator dependent suppression of
Shh target gene transcription
Tzingounis et al., Neuron 2006
:
These studies show that
Arc/Arg3.1 regulates
endophilin 3 and dynamin 2, two components of the endocytosis machinery ... These studies show that
Arc/Arg3.1 regulates endophilin 3 and
dynamin 2 , two components of the endocytosis machinery
Foo et al., J Biol Chem 2007
(Myocardial Reperfusion Injury) :
Here we show that degradation of
ARC is
dependent on the p53 induced ubiquitin E3 ligase,
MDM2 ... Furthermore,
ARC degradation
requires MDM2 , because MDM2 knock-out fibroblasts showed defective ARC degradation that could be rescued by MDM2
Jin et al., J Biol Chem 2007
:
In contrast, under the same assay conditions, partially purified
NAT from rat brain was highly
Ca2+ dependent , membrane associated, and specific for the sn-1-acyl group of PC ... These results reveal that RLP-1 can function as a PE N-acyltransferase, catalytically distinguishable from the known
Ca2+ dependent
NAT
Hunter et al., FEBS Lett 2007
:
ARC-overexpression inhibited myoblast differentiation associated
caspase-3 activation, suggesting ARC inhibits myogenic differentiation through caspase inhibition
Meng et al., Anticancer Drugs 2007
(Anoxia) :
ARC-111 , a small-molecule
topoisomerase I inhibitor , is a potent cytotoxic drug against multiple human cancer cell lines under normoxic conditions ( Li et al., Cancer Res 2003 ; 63 : 8400-8407 )
de Foubert et al., Neuroscience 2007
:
The present study investigated the
effects of
5-HT(6)-receptor activation on hippocampal and cortical levels of mRNA expression of BDNF and
Arc in the rat
Liu et al., Mol Cell Biol 2008
:
STAF65gamma is
required for SPT3/STAGA interaction with core
Mediator and for MYC recruitment of SPT3, TAF9, and core Mediator components to the TERT promoter but is dispensable for MYC recruitment of TRRAP, GCN5, and p300 and for acetylation of nucleosomes and loading of TFIID and RNA polymerase II on the promoter
Li et al., Aging Cell 2007
:
Aging up-regulated expression of Bax, Bcl2 and
ARC ,
down-regulated XIAP expression and did not affect p53, pp53 and Omi/HtrA2 ... Aging up-regulated expression of Bax, Bcl2 and
ARC , down-regulated XIAP expression and did not
affect p53 , pp53 and Omi/HtrA2 ... Aging up-regulated expression of Bax, Bcl2 and
ARC , down-regulated XIAP expression and did not
affect p53, pp53 and
Omi/HtrA2
Ge et al., Mol Cell Biol 2008
:
These results indicate that there is a conditional requirement for MED1/TRAP220 and that a direct interaction between PPARgamma and
Mediator through MED1/TRAP220 is not
essential either for PPARgamma stimulated adipogenesis or for
PPARgamma target gene expression in cultured fibroblasts ... As
Mediator is apparently
essential for
PPARgamma transcriptional activity, our data indicate the presence of alternative mechanisms for Mediator recruitment, possibly through intermediate cofactors or other cofactors that are functionally redundant with MED1/TRAP220
Mine et al., Metabolism 2008
(Disease Models, Animal...) :
Furthermore,
NAT also
up-regulated hepatic expression of the adiponectin receptor
AdipoR2 , although there was no effect on the plasma adiponectin level
Leite et al., J Neuroendocrinol 2008
:
ERalpha expression in TH-ir neurones
increased at 14 and 16 h in the
rostral-ARC and dorsomedial-ARC, 14 h in the caudal-ARC and 16 h in the VMPO, whereas it was unaltered in the ventrolateral-ARC, periventricular and AVPe
Echeverria et al., Curr Alzheimer Res 2007
:
Using a model of synaptic plasticity in which
BDNF increases
Arc expression in cultured cortical neurons, we have found that an oligomeric form of Abeta strongly inhibits the BDNF induced increase of Arc expression
Kaur et al., Dis Esophagus 2008
(Esophageal Neoplasms) :
Similarly, decreased
superoxide dismutase activity was observed in tumor tissue in
response to
NAT
Stehle et al., Neurosci Lett 1991
(Blindness) :
Neither this peptide nor
AVP alone did not affect NAT activity, but either substance
potentiated the norepinephrine induced enhancement of
NAT activity
Beltran et al., Genes Dev 2008
(Adenocarcinoma...) :
Ectopic overexpression of this
NAT in epithelial cells prevents splicing of the Zeb2 5'-UTR,
increases the levels of
Zeb2 protein, and consequently down-regulates E-cadherin mRNA and protein ... Therefore, the results presented in this article reveal the existence of a NAT capable of activating Zeb2 expression, explain the mechanism involved in this activation, and demonstrate that this
NAT regulates
E-cadherin expression
Belakavadi et al., Mol Cell Biol 2008
:
Here, we report that phosphorylation of
MED1 by mitogen activated protein kinase-extracellular signal regulated kinase ( MAPK-ERK )
promotes its association with
Mediator
Contreras-Levicoy et al., FEBS J 2008
:
Activation of transcription by
PC4 was
dependent on the
Mediator complex and TFIIA, but was independent of TATA binding protein associated factor
Keifer et al., Neurobiol Learn Mem 2008
(Synaptic Transmission) :
The results are consistent with the interpretation that synaptic incorporation of GluR4 containing AMPARs supports the expression of
CRs in this preparation, and that
Arc may be
involved in trafficking of GluR4 subunits during conditioning
Karanasios et al., J Mol Biol 2008
:
Furthermore, the C-terminal part of Arc1p harbors a conserved tRNA binding domain ( TRBD ) required for the
Arc1p dependent stimulation of the catalytic activity of
MetRS
Tsutsui et al., Genes Cells 2008
:
While the role of CDK8 has been studied extensively, little is known of the
role of
CDK11 in
Mediator
Thiaville et al., Nucleic Acids Res 2008
:
It is unclear whether
Mediator complex in yeast is
necessary for all
RNA polymerase II (Pol II) transcription or if it is limited to genes activated by environmental stress
Zheng et al., J Neurosci Res 2009
:
In contrast, chelating intracellular calcium ( [ Ca ( 2+ ) ] ( i ) ) by BAPTA-AM abolished
BDNF mediated
Arc up-regulation ... Surprisingly, BAPTA-AM did not block ERK activation, indicating that [ Ca ( 2+ ) ] ( i ) and Ras-Raf-MAPK are not coupled, and the activation of
ERK alone is not
sufficient to up-regulate
Arc transcription ... Moreover, we found that inhibition of
calmodulin (CaM) by W13
blocked both
Arc transcription and ERK activation, revealing a Ca ( 2+ ) -independent function of CaM
Ambati et al., Biofactors 2007
(Body Weight) :
Leptin and
CNTF increased
ARC-ME mRNA levels of signal transducer and activator of transcription 3 ( STAT3 ) by 64.5 and 124.7 % ( p < 0.01 ), suppressor of cytokine signaling 3 ( SOCS3 ) by 258.9 and 1063.9 % ( p < 0.01 ), cocaine and amphetamine regulated transcript ( CART ) by 102.7 and 123.1 % ( p < 0.01 ), and proopiomelanocortin ( POMC2 ) by 374.1 and 264.9 % ( p < 0.01 ), respectively ...
Leptin and CNTF
increased ARC-ME mRNA levels of signal transducer and activator of transcription 3 ( STAT3 ) by 64.5 and 124.7 % ( p < 0.01 ), suppressor of cytokine signaling 3 ( SOCS3 ) by 258.9 and 1063.9 % ( p < 0.01 ), cocaine and amphetamine regulated transcript ( CART ) by 102.7 and 123.1 % ( p < 0.01 ), and proopiomelanocortin ( POMC2 ) by 374.1 and 264.9 % ( p < 0.01 ), respectively
Messerli et al., Phytother Res 2009
(Neoplasms, Experimental...) :
Artepillin C (ARC) in Brazilian green propolis selectively
blocks oncogenic
PAK1 signaling and suppresses the growth of NF tumors in mice ... Also it was demonstrated that ARC suppresses angiogenesis, suggesting the possibility that
ARC also
blocks oncogenic
PAK1 signaling ... Here it is shown for the first time that both
ARC and green propolis extract ( GPE ) indeed
block the
PAK1 signaling selectively, without affecting another kinase known as AKT
Camp et al., J Neuroendocrinol 1991
:
Activation of
adenylate cyclase by forskolin or addition of a cyclic AMP analogue
increased both melatonin release and
NAT activity
Chen et al., J Neurosci Res 2009
:
In this study,
BDNF treatment alone
induced the activation of the phosphatidylinositol 3-kinase-Akt-mammlian target of rapamycin ( PI3K-Akt-mTOR ) signaling pathway, the phosphorylation of eukaryotic initiation factor 4E binding protein ( 4EBP1 ) and p70 ribosomal S6 kinase (p70S6K), the dephosphorylation of eukaryotic elongation factor 2 ( eEF2 ), and the expression of
Arc
Simpson et al., Arq Bras Endocrinol Metabol 2009
(Obesity) :
Firmly established pathways
involve the orexigenic
NPY/AgRP and the anorexigenic POMC/CART neurons in the
arcuate nucleus (ARC) of the hypothalamus ... Firmly established pathways
involve the orexigenic
NPY/AgRP and the anorexigenic POMC/CART neurons in the
arcuate nucleus (ARC) of the hypothalamus
Kirk et al., PloS one 2009
(Hyperphagia...) :
At postnatal Day 30, before the onset of hyperphagia in these animals, serum
leptin is normal, but leptin induced appetite suppression and phosphorylation of STAT3 in the
arcuate nucleus (ARC) are
attenuated ; the level of AgRP-immunoreactivity in the hypothalamic paraventricular nucleus ( PVH ), which derives from neurones in the ARC and is developmentally dependent on leptin, is also diminished
Alarma-Estrany et al., J Pineal Res 2009
:
5-MCA-NAT does not
act through
NQO2 to reduce intraocular pressure in New-Zealand white rabbit ... Altogether, the results led us to conclude that the in vivo effect of the MT(3) ligand
5-MCA-NAT on IOP is not
mediated by the enzyme
NQO2 , suggesting the existence of another melatonin receptor
Villanueva et al., Endocrinology 2009
:
Furthermore, ghrelin, which activates orexigenic ARC neurons, increased
ARC mTORC1 activity and
induced colocalized pS6- and
c-Fos-IR
Wakamura et al., J Pharmacobiodyn 1990
:
Ebselen and
NAT06-123 also markedly
inhibited nicotinamide adenine dinuclestide phosphate (
NADPH ) oxidase activity, which is responsible for O2- production in intact cells, and in a particulate fraction prepared from TPA stimulated PMNL, whereas PZ-25 inhibited this enzyme weakly and NAT02-761 did not
Panja et al., J Biol Chem 2009
:
These results support a dominant
role for
ERK-MNK signaling in control of translational initiation and
Arc synthesis during LTP consolidation in the dentate gyrus ... These results support a dominant
role for
ERK-MNK signaling in control of translational initiation and
Arc synthesis during LTP consolidation in the dentate gyrus
Frank et al., Brain Behav Immun 2010
(Escherichia coli Infections...) :
IL-1RA blocks E. coli
induced suppression of
Arc and long-term memory in aged F344xBN F1 rats
Schwartz et al., Endocrinology 1991
(Obesity) :
Thus,
insulin reduced the expression of mRNA for NPY specifically in the
ARC
Kim et al., J Cell Physiol 2010
(Colonic Neoplasms) :
Indeed,
ARC-G blocked expression of UPR target genes such as phosphorylated-PERK, ATF4,
CHOP , and GRP78, which was accompanied by enhanced phosphorylation of eIF2 alpha during glucose deprivation ... Indeed,
ARC-G blocked expression of UPR target genes such as phosphorylated-PERK, ATF4, CHOP, and
GRP78 , which was accompanied by enhanced phosphorylation of eIF2 alpha during glucose deprivation ... Indeed,
ARC-G blocked expression of UPR target genes such as phosphorylated-PERK,
ATF4 , CHOP, and GRP78, which was accompanied by enhanced phosphorylation of eIF2 alpha during glucose deprivation
Qi et al., Endocrinology 2010
:
It is widely accepted that
leptin acts on first-order neurons in the
arcuate nucleus (ARC) with information then relayed to other hypothalamic centers ... We used a model of hypothalamo-pituitary disconnection ( HPD ) to determine whether
leptin action on appetite regulating systems
requires the
ARC
Suzuki et al., Toxicol Pathol 2010
(Body Weight...) :
MeIQx is metabolically
activated by
CYP1A2 and then
N-acetyltransferase (NAT) , findings that suggest that its carcinogenic potential might be enhanced by simultaneous exposure to chemical ( s ) inducing CYP1A2
Li et al., Apoptosis 2010
:
ARC ( apoptosis repressor with caspase recruitment domain ), an abundantly expressed apoptotic repressor in cardiomyocytes, could
inhibit mitochondrial fission and
Smac/DIABLO release
Carey et al., Cold Spring Harbor protocols 2010
:
INTRODUCTION : The
Mediator ( Med ) complex plays a key role in promoter-specific activation of transcription by
RNA polymerase II (Pol II)
Kunin et al., PloS one 2010
:
Mediator of DNA damage checkpoint 1 ( MDC1 )
contributes to high NaCl induced activation of the osmoprotective transcription factor
TonEBP/OREBP
Brewster et al., Virology 2011
:
Cdk8 is
dependent upon
cyclin C and regulates transcription with the Mediator complex, a co-activator of transcription
Arzamendi et al., Clin Appl Thromb Hemost 2011
(Coronary Artery Disease...) :
In contrast to abciximab,
ARC1779 did not significantly
affect platelet aggregation,
P-selectin expression, and platelet-leukocyte binding
Xu et al., EMBO Rep 2011
(Alzheimer Disease) :
Mediator , in a
MED12 dependent manner, occupies only AICD bound promoter DNA, indicating that the AICD recruits Mediator to activate transcription
Harlan et al., Circ Res 2011
(Disease Models, Animal...) :
These data demonstrate a critical
role for
ObR in the
ARC in mediating the sympathetic nerve responses to leptin and in the adverse sympathoexcitatory effects of leptin in obesity
Alberi et al., Neuron 2011
:
Thus, Notch signaling is dynamically regulated in response to neuronal activity,
Arc/Arg3.1 is a context dependent Notch regulator, and
Notch1 is
required for the synaptic plasticity that contributes to memory formation
Quennell et al., Endocrinology 2011
(Body Weight...) :
In mice with normalized levels of estradiol,
leptin deficiency markedly
reduced kisspeptin gene expression, particularly in the
arcuate nucleus (ARC) , and kisspeptin immunoreactive cell numbers in the rostral periventricular region of the third ventricle ( RP3V )
Roth et al., Pediatr Res 2011
(Body Weight...) :
We compared the metabolic phenotype of animals with three distinct types of hypothalamic lesions : 1 ) destruction of the
arcuate nucleus (ARC) induced by monosodium glutamate ( MSG ), 2 ) electrolytic lesion of the adjacent ventromedial nucleus ( VMN ) alone, 3 ) both the VMN and
dorsomedial nucleus (DMN) , or a 4 ) combined medial hypothalamic lesion ( CMHL ) affecting the VMN, DMN, and the ARC
Zheng et al., Curr Eye Res 2011
(Cataract) :
Its downstream p53 was inhibited, and FOXO pathway was activated, indicating that
SIRT1 may
play a protective role in
ARC formation
Andino et al., J Endocrinol 2011
(Body Weight...) :
Interestingly, tyrosine hydroxylase levels were
increased in both the
ARC and VTA with
POMC overexpression in either the ARC or the VTA
Corbin et al., International journal of nephrology and renovascular disease 2011
:
Active renin mass concentration (ARC) is
independent of the endogenous level of
angiotensinogen , and less variable and more reproducible than plasma renin activity
Resch et al., Am J Physiol Regul Integr Comp Physiol 2011
:
One hour after PACAP administration, expression of pro-opiomelanocortin mRNA was significantly
increased in the
arcuate nuclei (ARC) , with no changes in
neuropeptide Y and agouti related polypeptide mRNA levels
Lin et al., Genes Dev 2011
:
Studies in depleted extracts showed that the
Mediator coactivator complex, which controls PIC assembly, is also
necessary for
CHD1 recruitment
Kumar et al., J Biol Chem 2012
(Synaptic Transmission) :
Moreover, intracellular mGluR5 induced
Arc expression
requires the serum response
transcription factor ( SRF ) as wild type but not SRF-deficient neurons show this response ... Moreover, intracellular
mGluR5 induced
Arc expression requires the serum response transcription factor ( SRF ) as wild type but not SRF-deficient neurons show this response ... Mechanistically, intracellular mGluR5 mediated Arc induction is dependent upon extracellular and intracellular Ca ( 2+ ) and ERK1/2 as well as calmodulin dependent kinases as known chelators, inhibitors, and a dominant negative Ca ( 2+ )
/calmodulin dependent protein kinase II construct block
Arc increases ... Mechanistically, intracellular mGluR5 mediated
Arc induction is
dependent upon extracellular and intracellular Ca ( 2+ ) and
ERK1/2 as well as calmodulin dependent kinases as known chelators, inhibitors, and a dominant negative Ca ( 2+ ) /calmodulin dependent protein kinase II construct block Arc increases ... Mechanistically, intracellular
mGluR5 mediated
Arc induction is dependent upon extracellular and intracellular Ca ( 2+ ) and ERK1/2 as well as calmodulin dependent kinases as known chelators, inhibitors, and a dominant negative Ca ( 2+ ) /calmodulin dependent protein kinase II construct block Arc increases
Yi et al., Diabetes 2012
(Insulin Resistance) :
Antagonizing the
NPY1 receptors by intracerebroventricular infusion of its antagonist largely
blocked the hepatic insulin resistance induced by dexamethasone in the
ARC
Pandorf et al., Am J Physiol Regul Integr Comp Physiol 2012
(Hypothyroidism) :
A comparative phylogenetic analysis also suggests that
bII NAT mediated
regulation has been a conserved trait of placental mammals for most of the eutherian evolutionary history
An et al., Hepatology 2012
(Disease Models, Animal...) :
Here, we investigated the in vivo
effects of
ARC fused with the transduction domain of human immunodeficiency virus 1 ( HIV-1 ) ( TAT-ARC ) on
Fas- and tumor necrosis factor (TNF) mediated murine models of fulminant liver failure
Ang et al., PLoS Biol 2012
:
Furthermore, we have found that
Mediator controls the galactose induced protein degradation of
Gal80 , which places Mediator genetically upstream of the activator Gal4 ... Furthermore, we have found that
Mediator controls the galactose induced protein degradation of Gal80, which places Mediator genetically upstream of the activator
Gal4
Holloway-Erickson et al., Frontiers in behavioral neuroscience 2012
:
Memory modulating BLA manipulations influence expression of the protein product of the immediate early gene activity regulated cytoskeletal associated protein (
Arc ) in the dorsal hippocampus, and hippocampal expression of
Arc protein is critically
involved in memory consolidation and long-term potentiation
Riediger et al., Proc Nutr Soc 2012
(Obesity...) :
PYY and
leptin also reverse or
prevent fasting induced activation of the
ARC ...
PYY and leptin also reverse or
prevent fasting induced activation of the
ARC
Chen et al., RNA 2012
:
Moreover, we observed biochemical association between Integrator proteins and
cyclin C/Cdk8 , and that overexpression of a kinase-dead
Cdk8 causes snRNA misprocessing
Tong et al., J Neurosci 2012
:
Using rat organotypic hippocampal cultures, we found that
IL-1ß suppressed BDNF dependent regulation of
Arc and phosphorylation of cofilin and cAMP response element binding protein ( CREB ), a transcription factor regulating Arc expression ... Using rat organotypic hippocampal cultures, we found that IL-1ß suppressed
BDNF dependent regulation of
Arc and phosphorylation of cofilin and cAMP response element binding protein ( CREB ), a transcription factor regulating Arc expression ... Using rat organotypic hippocampal cultures, we found that IL-1ß suppressed BDNF dependent regulation of Arc and phosphorylation of cofilin and cAMP response element binding protein ( CREB ), a
transcription factor regulating
Arc expression
Lewis et al., Clin Exp Allergy 2013
:
Mediator release
induced by
SCF was accompanied by the up-regulation of the activation marker, CD63
Tikhonova et al., Chin J Physiol 2012
:
BDNF also
augmented mRNA levels of
Arc gene encoding Arc ( Activity regulated cytoskeleton associated ) protein involved in BDNF induced processes of neuronal and synaptic plasticity in hippocampus and prefrontal cortex
Lu et al., J Biol Chem 2013
(Calcium Signaling...) :
Moreover, we showed that
Foxo3a activates
ARC expression by directly binding to its promoter
Kim et al., J Biol Chem 2013
:
Mediator recruitment to heat shock genes
requires dual Hsf1 activation domains and mediator tail subunits
Med15 and Med16 ...
Mediator recruitment to heat shock genes
requires dual Hsf1 activation domains and mediator tail subunits Med15 and
Med16
Verger et al., Nucleic Acids Res 2013
:
We further show that depletion of
MED25 disrupts the association of ERM with the
Mediator in vitro
Galbraith et al., Cell 2013
(Neoplasms) :
HIF1A Employs
CDK8-Mediator to
Stimulate RNAPII
Elongation in Response to Hypoxia ...
HIF1A induces binding of
CDK8-Mediator and the super elongation complex ( SEC ), containing AFF4 and CDK9, to alleviate RNAPII pausing
Šedý et al., J Immunol 2013
(Inflammation) :
CD160 Activation by Herpesvirus Entry
Mediator Augments Inflammatory Cytokine Production and Cytolytic Function by NK Cells
Blum et al., Proc Natl Acad Sci U S A 1989
(Chromosome Deletion) :
The relationship of a recently isolated cDNA clone, designated rnat, to genetically polymorphic arylamine N-acetyltransferase ( NAT ; acetyl-CoA : arylamine N-acetyltransferase, EC 2.3.1.5 ) of rabbit liver was established by its expression in monkey kidney COS-1 cells : ( i ) cytosols from transfected cultures contained high levels of an
Ac-CoA dependent
NAT activity, which was kinetically indistinguishable from that observed in cytosols from livers of genetically rapid-acetylator rabbits ; ( ii ) transfected cells also contained an immunoreactive protein, recognized by NAT-specific antibodies, with identical electrophoretic mobility to NAT from rabbit liver
Pan et al., Neuroendocrinology 1986
:
In the
ARC , however,
CCK-8S may
play some functional roles that are influenced by estrogen
Newman et al., Endocrinology 1985
:
Mediator generation was rapid, with a half-time of approximately 45 sec and was
insulin dose
dependent
Hein et al., J Pharmacol Exp Ther 1986
:
Acetyl
CoA dependent p-aminobenzoic acid and p-aminosalicylic acid
N-acetyltransferase (NAT) activity was determined in peripheral blood and blood cells from homozygous rapid ( RR ) acetylator ( Bio. 87.20 ) and homozygous slow ( rr ) acetylator ( Bio. 82.73/H ) inbred hamsters and in their F1, F2 and backcross progeny
Wainwright et al., J Neurochem 1984
:
EGTA or additional
Ca2+ had no effect on pineal
NAT activity
Voisin et al., J Neurochem 1993
:
In indomethacin treated cells,
PGs caused a four-fold increase in
NAT activity ... As a result, half-maximal
stimulation of
NAT by
PGs was not associated with an increase in cAMP levels ... These results indicate that an increase in cAMP levels may be responsible for the maximal stimulation of NAT evoked by PGs, whereas half-maximal
stimulation of
NAT by
PGs would rely principally on a calcium/calmodulin dependent mechanism
Yuwiler et al., J Neurochem 1995
:
Maximal
stimulation of rat pineal
NAT by
PACAP-38 is not increased further significantly by concurrent stimulation with the two related peptides, vasoactive intestinal polypeptide (VIP) and/or peptide N-terminal histidine C-terminal isoleucine ( PHI ) ... Prior
stimulation of rat pineal
NAT activity with
VIP , PHI, or PACAP-38 reduces the magnitude of subsequent stimulation with PACAP-38 or forskolin ... Prior
stimulation of rat pineal
NAT activity with VIP, PHI, or
PACAP-38 reduces the magnitude of subsequent stimulation with PACAP-38 or forskolin ... Prior
stimulation of rat pineal
NAT activity with VIP,
PHI , or PACAP-38 reduces the magnitude of subsequent stimulation with PACAP-38 or forskolin
Kalra et al., Brain Res 1994
:
The results showed that
IL-1 beta increased NKA-li selectively in the median eminence ( ME ) and
arcuate nucleus (ARC) of castrated rats only. ( ABSTRACT TRUNCATED AT 250 WORDS )
Molinero et al., Neurosci Lett 1993
(Hypothyroidism) :
The
effect of
vasoactive intestinal peptide (VIP) on thyroxine type II 5'-deiodinase (5'-D) and
N-acetyltransferase (NAT) activities were studied using pineal cells of euthyroid and hypothyroid rats ... Both 5'-D and
NAT activities were
stimulated not only by
VIP , but also by isoproterenol, a beta-adrenergic receptor agonist, and forskolin, a potent activator of adenylate cyclase activity
Walter et al., Pharmazie 1996
:
NAT was significantly
inhibited by CP ( given 5 d before sacrifice ) but not by
plC , SLO or CP when given 2 d before sacrifice ...
NAT was significantly
inhibited by CP ( given 5 d before sacrifice ) but not by plC,
SLO or CP when given 2 d before sacrifice
Walter et al., Immunopharmacol Immunotoxicol 1996
:
Both
IFN gamma and SLO
activated NAT to 120 % ( P < 0.05 ) and 135 % ( P < 0.05 ), respectively ... Both IFN gamma and
SLO activated
NAT to 120 % ( P < 0.05 ) and 135 % ( P < 0.05 ), respectively ... The results suggested that not only the toxin of gram positive streptococcal bacteria SLO, but also the cytokine
IFN gamma can
stimulate NAT activity in rat hepatic cytosol ... While the enhancing SLO effect on NAT could not be neutralized by the inhibitor of transcription actinomycin D,
NAT stimulation by
IFN gamma was abolished by actinomycin D and by the inhibitor of translation, cycloheximide ... While the enhancing
SLO effect on
NAT could not be neutralized by the inhibitor of transcription actinomycin D, NAT stimulation by IFN gamma was abolished by actinomycin D and by the inhibitor of translation, cycloheximide ... Obviously,
SLO activated
NAT independent of protein synthesis and different from IFN gamma mediated pathways
Foulkes et al., Proc Natl Acad Sci U S A 1996
:
In addition, transfection studies show that
ICER powerfully
represses NAT transcription
Minami et al., J Endocrinol 1997
:
Together with the results of our previous studies showing that c-fos gene expression was induced by systemic administration of GH and that GH receptor mRNA was contained in somatostatin neurons in the PeV and NPY neurons in the ARC, the data of the present study indicate that GH, but not
IGF-I ,
acts on the cells in the
ARC and the PeV or in their vicinity to inhibit its own secretion, presumably by activating the somatostatin and NPY neurons
Lin et al., Sheng Li Xue Bao 1996
:
In this group, brain
ANP increased in the periventricular nuclues ( PVN ) and
arcute nucleus (Arc) ( P < 0.05 )
Sahu et al., Endocrinology 1998
:
In addition, in the
ARC and MPOA, the other hypothalamic sites associated with induction of LH surge,
NPY levels
increased before and during the LH surge in young rats, no change in NPY levels in these nuclei was observed in association with the attenuated LH surge in MA rats
Abdel-Rahman et al., Mutat Res 1998
(Chromosome Aberrations...) :
Of these alleles,
NAT1*10 is
responsible for increased
NAT1 enzyme levels and is reported to be associated with increased risk for colorectal and bladder cancers
Kim et al., Brain Res 1998
(Hyperphagia) :
Animals receiving the HPD ad libitum consumed more calories and gained more weight than animals receiving the BCD ( P < 0.001 ). The
HPD did not
affect ARC NPY mRNA levels, whether the subjects were allowed to overeat or pair fed to the BCD ( P > 0.05 )
Elias et al., Neuron 1998
(Body Weight) :
We found that
leptin activates neurons in the retrochiasmatic area ( RCA ) and lateral
arcuate nucleus (Arc) that innervate the thoracic spinal cord and also contain cocaine- and amphetamine regulated transcript ( CART )
Han et al., Mol Cell Biol 1999
:
The multisubunit
Mediator complex of Saccharomyces cerevisiae is
required for most
RNA polymerase II (Pol II) transcription
Liu et al., Cancer Lett 1998
:
In sonicate from transiently transfected COS cells,
NAT1 increased
CYP1A2 catalyzed adduct formation 4-fold while NAT2 increased adduct formation 12-fold