Gene interactions and pathways from curated databases and text-mining

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CAV2 — PRKCA

Text-mined interactions from Literome

Sukumaran et al., J Biol Chem 2002 (Escherichia coli Infections) : Overexpression of a dominant negative form of caveolin-1 containing mutations in the scaffolding domain blocked the interaction of phospho-PKCalpha with caveolin-1 and the E. coli invasion of HBMEC, but not actin cytoskeleton rearrangement or the phosphorylation of PKCalpha
Tourkina et al., J Biol Chem 2005 (Fibrosis...) : In another, increased PKCalpha induces caveolin-1 expression, which in turn inhibits MEK/ERK activation and collagen expression
Wang et al., Cancer Res 2007 (Carcinoma, Squamous Cell) : Within this ordered complex of signaling molecules, the ability of CD82 to associate with PKC-alpha requires the presence of caveolin-1 , whereas the interaction of caveolin-1 or PKC-alpha with EGFR requires the presence of CD82 and ganglioside GM3