Gene interactions and pathways from curated databases and text-mining

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CAV1 — NGF

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: CAV1 → NGF (increases) Tan et al., J Biol Chem 2003*
    Evidence: Nerve Growth Factor Blocks the Glucose- induced Down-regulation of Caveolin-1 Expression in Schwann Cells via p75 Neurotrophin Receptor Signaling * Wenbin Tan , Shefali Rouen , Kristin M.

Text-mined interactions from Literome

Tan et al., J Biol Chem 2003 (Diabetes Mellitus, Experimental) : Intriguingly, nerve growth factor antagonized the enhanced mitogenic response of SCs to neuregulin1-beta1 and inhibited the glucose induced down-regulation of Cav-1 transcription, mRNA, and protein expression through p75NTR dependent activation of JNK
Schmitz et al., Cell Mol Neurobiol 2011 : On the other hand, an over-expression of caveolin-1 impaired the NGF stimulated activity of p42/44 mitogen activated protein kinases ( MAPK )