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CA2 — RAD50
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Oestreich et al., J Biol Chem 2009
(Calcium Signaling) :
Here we demonstrate that PLCepsilon phosphatidylinositol 4,5-bisphosphate hydrolytic activity and PLCepsilon stimulated
Rap1 GEF activity are both
required for PLCepsilon mediated enhancement of sarcoplasmic reticulum
Ca2+ release and that PLCepsilon significantly enhances Rap activation in response to betaAR stimulation in the heart
Guidetti et al., Biochem J 2013
:
In blood platelets the small GTPase
Rap1b is
activated by cytosolic
Ca2+ and promotes integrin aIIbß3 inside-out activation and platelet aggregation
Moyers et al., Biochem J 1998
:
We have recently shown that
Rad and Gem bind calmodulin in a
Ca2+ dependent manner via this C-terminal extension, involving residues 278-297 in human Rad
Kawasaki et al., Proc Natl Acad Sci U S A 1998
:
We propose that CalDAG-GEF proteins have a critical neuronal function in determining the relative activation of Ras and
Rap1 signaling
induced by
Ca2+ and DAG mobilization