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BRCA1 — SMC5

Text-mined interactions from Literome

Kitagawa et al., Genes Dev 2004 (Chromosome Aberrations) : Here, we show that NBS1 and BRCA1 are required for the recruitment of previously activated ATM to the sites of DNA breaks after ionizing irradiation, and that this recruitment is required for the phosphorylation of SMC1 by ATM
Antoccia et al., Radiat Res 2008 (Chromosome Aberrations...) : It is noted that BRCA1 is required for the interaction of NBS1 with SMC1 , whereas the reverse is not the case, since BRCA1 is able to bind to NBS1 in the absence of an NBS1/SMC1 interaction as observed in MRE11- or RAD50-deficient cells ... Our results reveal that ATM plays a fundamental role in promoting the radiation induced interaction of NBS1 with SMC1 in the presence of BRCA1 , leading to the maintenance of chromosomal integrity