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BCAR3 — SRC

Text-mined interactions from Literome

Schuh et al., J Biol Chem 2010 (Breast Neoplasms) : BCAR3 regulates Src/p130 Cas association, Src kinase activity, and breast cancer adhesion signaling ... In this study, we show for the first time using gain- and loss-of-function approaches that BCAR3 regulates c-Src activity in the endogenous setting of breast cancer cells
Makkinje et al., J Biol Chem 2012 : Although our prior work identified phosphorylation of the serine within the p130 ( cas ) RPLPSPP motif, mutation of this residue to alanine or glutamic acid did not alter BCAR3 induced Src SH3 domain binding to p130 ( cas ) ... Our work suggests that BCAR3 expression may regulate Src signaling in a BCAR3-p130 ( cas ) complex dependent fashion by altering the ability of the Src SH3 domain to bind the p130 ( cas ) SBD