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ARF6 — MAPK1

Pathways - manually collected, often from reviews:

• NCI Pathway Database Arf6 downstream pathway: Erk1-2 (MAPK3/MAPK1) → ARF6/GTP complex (ARF6) (modification, collaborate) Tague et al., Proc Natl Acad Sci U S A 2004*, Li et al., Cancer Res 2006*, Tushir et al., EMBO J 2007
  Evidence: genetic interaction, assay
• NCI Pathway Database Arf6 downstream pathway: ARF6/GTP complex (ARF6) → Erk1-2-active (MAPK3/MAPK1) (modification, activates)
  Tague et al., Proc Natl Acad Sci U S A 2004*, Li et al., Cancer Res 2006*, Tushir et al., EMBO J 2007
  Evidence: genetic interaction, assay

Text-mined interactions from Literome

Tzachanis et al., J Immunol 2003 : Forced expression of ARF6-GTP in primary human T cells inhibited extracellular signal regulated kinase1/2 activation and proliferative responses
Daher et al., Cell Signal 2008 : In non stimulated cells, depletion of ARF6 leads to increased FAK and Erk1/2 phosphorylation, similar to what is observed in ET-1 treated cells