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APP — BDNF
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Ruiz-León et al., J Neurochem 2001
(Neuroblastoma) :
The APP promoter contains two potential AP-1 sites, and we examined whether or not protein kinase C ( PKC ) and the AP-1 sites of the promoter mediate the
BDNF induced stimulation of
APP ...
Stimulation of
APP promoter activity by
BDNF was not affected by the PKC inhibitor bisindolylmaleimide, or by dominant negative mutants of the AP-1 components Fos and Jun, which, however, blocked the response to phorbol esters ... These results suggest that
activation of the
APP promoter by
BDNF is largely independent of PKC and AP-1
Ruiz-León et al., J Neurochem 2004
(Neuroblastoma) :
A substitution of the Y484 residue by phenylalanine, which blocks binding of Shc, reduces the
activation of
APP promoter by
BDNF by approximately 50 % whereas mutation Y785P, which blocks binding of phospholipase C gamma, does not affect the response ... Taken together, our results suggest that simultaneous activation of at least two signalling pathways, Ras/MAPK and PI3K/Akt, is necessary to mediate a full
activation of the
APP promoter by
BDNF