Gene interactions and pathways from curated databases and text-mining

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APOB — CRP

Text-mined interactions from Literome

van Tits et al., Arterioscler Thromb Vasc Biol 2005 : These findings suggest that : ( 1 ) CRP and annexin A5 at physiological concentrations bind to distinct sites of negatively charged phospholipids present in oxidized LDL ; ( 2 ) CRP enhances binding of oxidized LDL to monocytic/macrophage-like cells via Fcgamma receptors ; and ( 3 ) annexin A5 does not antagonize the CRP induced enhanced binding of oxidized LDL to U937 cells
Ji et al., Int J Biochem Cell Biol 2006 (Atherosclerosis) : Interaction of modified C-reactive protein and low-density lipoprotein was mediated synergistically by both electrostatic association with ApoB and hydrophobic insertion into lipid layer
Pontet et al., Biochimie 1979 : Moreover, CRP in the serum is shown to be in the bound form only, and the binding involves Low Density Lipoproteins (LDL) exclusively
Mookerjea et al., Arterioscler Thromb 1994 : Rat C-reactive protein causes a charge modification of LDL and stimulates its degradation by macrophages ... The degradation of the modified 125I-LDL by rat peritoneal macrophages was increased more than twofold in the presence of rat CRP ... In contrast, the degradation of 125I-acetyl-LDL by macrophages was not affected by rat CRP , although acetylated LDL inhibited the rat CRP stimulated degradation of 125I-LDL